European Molecular Biology Organization


50 Years of X–inactivation Research

20 - 24 July 2011 | Oxford | United Kingdom



20 July | 21 July | 22 July | 23 July | 24 July


Wednesday, 20 July
12:00 - 16:30 Registration in the Porters Lodge, St.Catherine's College
15:30 - 16:30 Refreshments
16:30 – 16:40 Welcome and opening remarks
Session I
X inactivation and reprogramming (Chair: NEIL BROCKDORFF)
16:40– 17:20 Azim SURANI  (Wellcome Trust Cancer Research UK Gurdon Institute, UK) Principles and programming of the mammalian germ line (Plenary talk)
17:25 - 17:45 Phil AVNER  (Institut Pasteur, France) Early events in random X-inactivation onset
17:50 - 18:05 Susana CHUVA DE SOUSA LOPES  (Leiden University Medical Center, Netherlands) Germ cells in the urogenital region that undergo X chromosome reactivation enter meiosis
18:10 - 18:30 Wolf REIK  (Babraham Institute, UK) Mechanisms and functions of epigenetic reprogramming in mammalian development
18:35 - 18:50 Pablo NAVARRO  (University of Edinburgh, UK) Plugging X-inactivation regulators into the pluripotency circuitry
19:00 DINNER
Thursday, July 21
Session II
Developmental regulation of X inactivation (A)  (Chair: JEANNIE LEE)
7:45 – 8:30 BREAKFAST
8:30 - 8:50 Joost GRIBNAU  (Erasmus MC, Netherlands) Activation of X Inactivation
8:55 - 9:10 Claire ROUGEULLE  (CNRS/Universite Paris Diderot, France) Functional analysis of Ftx, a conserved non-coding RNA within the X-inactivation centre which affects Xist expression
9:15 - 9:35 Takashi SADO  (Kyushu University, Japan) X-inactivation initiated by Xist RNA defective in silencing in the mouse embryo
9:40 - 9:55 Christina SHEEDY  (Duke University, USA) Genomic characterization of the Xce candidate region
10:00 - 10:20 Ingolf BACH  (University of Massachusetts Medical School, USA) Sex-specific parent-of-origin effects of Rnf12/RLIM in female mice
Session III
Developmental regulation of X inactivation (B) (Chair: EDITH HEARD)
11:00 – 11:20 Barbara PANNING  (University of California, USA) The A-repeat links ASF/SF2-dependent Xist RNA processing with random choice during X inactivation
11:25 - 11:40 Tatsuya OHHATA  (The Wellcome Trust Centre for Stem Cell Research, UK) Lineage-specific function of the noncoding Tsix RNA for Xist repression and Xi reactivation in mice
11:45 - 12:05 Graham KAY  (Queensland Institute of Medical Research, Australia) Smchd1 is essential for X inactivation, but also much more
12:10 - 12:25 Elphege NORA  (Institut Curie, France) Investigating the structural and regulatory landscape of the X-inactivation center at the onset of X inactivation
12:45 LUNCH
13:30-14:50 POSTER SESSION A
Session IV
Chromatin studies (Chair: BRYAN TURNER)
15:00 – 15:20 Thomas JENUWEIN  (Max Planck Institute of Immunbiology and Epigenetics, Germany)  Epigenetic control by histone methylation
15:25 - 15:40 Ligia TAVARES  (University of Oxford, UK) PRC1 is recruited to target loci in mouse embryonic stem cells independent of H3K27me3
15:45 - 16:05 Adrian BIRD  (Wellcome Trust Centre for Cell Biology, UK) The Functional Significance of CpG Islands
16:10- 16:25 Sundeep KALANTRY   (University of Michigan Medical School, USA) Discovery of a novel methyltransferase enriched on the inactive X-chromosome
Session V
17:00 – 17:20 Jeannie LEE  (Howard Hughes Medical Institute and Harvard Medical School,USA) Regulation of X-chromosome inactivation by long noncoding RNA
17:25 - 17:40 Stefan BARAKAT  (Erasmus MC, Netherlands) RNF12 activates Xist and is essential for X inactivation
17:45 - 18:05 Ingrid GRUMMT  (German Cancer Research Center, Germany) Noncoding RNA targets chromatin modifying enzmes to regulatory gene sequences
18:10 - 18:25 Anne SAVOYE  (AREMS UMR, France) Structure/function analysis of the A region of Xist RNA
18:30 - 18:50 Asifa AKHTAR  (Max Planck Institute of Immunobiology, Germany) Dosage compensation in Drosophila
19:00 DINNER
Friday, July 22
Session VI
Evolution of X inactivation (Chair: ANNE FERGUSON-SMITH)
7:45 – 8:30 BREAKFAST
8:30 - 8:50 Jenny GRAVES  (Australian National University & La Trobe University, Australia) Evolution of dosage compensation in mammals
8:55 - 9:10 Bryan TURNER  (University of Birmingham, UK) Up-regulated expression of X-linked genes in mice preserves the X:A balance but creates a need for X inactivation
9:15 - 9:35 James TURNER  (MRC National Institute for Medical Research, UK) X inactivation in the germline and soma
9:40 - 9:55 Satoshi NAMEKAWA  (Cincinnati Children’s Hospital Medical Center, USA) MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells
10:00 - 10:20 Barbara MEYER  (HHMI and University of California, USA) Targeting X chromosomes for repression in nematode species
11:00 - 12:40 A series of recollections and stories from pioneers of the field  followed by commemorative awards
12:50 - 13:00 Coach trip to the Cherwell Boat House
13:00 - 13:30 Reception drinks at Cherwell Boat House
13:30 - 18:30 Sit down lunch followed by informal discussion groups and punting on river Cherwell
Saturday, July 23
Session VII
Chromosome silencing by Xist (A) (Chair: HUNT WILLARD)
7:45 – 8:30 BREAKFAST
8:30 - 8:50 Anton WUTZ  (Wellcome Trust Centre for Stem Cell Research, UK) Gene silencing by the noncoding Xist RNA in embryonic and adult stem cells
8:55 - 9:10 Anne-Valerie GENDREL  (University of Oxford, UK & Institut Curie, France) Smchd1 dependent and independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome
9:15 - 9:35 Carolyn BROWN  (University of British Columbia, Canada) Cis-acting Elements Involved in Human X-Chromosome Inactivation
9:40 - 9:55 Laura CARREL  (Penn State College of Medicine & Penn State University, USA) Comparative analysis of an escape gene domain; rodents are outliers
10:00 - 10:20 Christine DISTECHE  (University of Washington and Fred Hutchinson Cancer Research Center, USA) Genes that escape X inactivation
Session VIII
Chromosome silencing by Xist (B) (Chair: JOOST GRIBNAU)
11:00 – 11:20 Hunt WILLARD  (Duke University, USA) Chromosomal Control of X Inactivation: Unanswered Questions, Unsolved Challenges
11:25 - 11:40 Marnie BLEWITT (Walter & Eliza Hall Institute of Medical Research, Australia) A targeted RNAi screen for novel epigenetic modifiers involved in X inactivation
11:45 - 12:05 Jeanne LAWRENCE (University of Massachusetts Medical School, USA) Repeat DNAs and RNAs in Chromosome Structure and Regulation
12:10 - 12:25 Hendrik MARKS  (Radboud University, NCMLS, Netherlands) The neXt generation of X-inactivation
12:45 LUNCH
13:30-14:50 POSTER SESSION B
Session IX
X inactivation and imprinting (Chair: ANTON WUTZ)
15:00 – 15:20 Denise BARLOW  (Research Center for Molecular Medicine of the Austrian Academy of Science, Austria) Genomic imprinting: an epigenetic gene regulatory modely
15:25 - 15:40 Savita BAGGA  (Sigma-Aldrich, USA) Imprint® Ultra Chromatin Immunoprecipitation kit: A Highly Sensitive Kit Optimized for Deep Sequencing
15:45 - 16:05 Anne FERGUSON-SMITH  (University of Cambridge, UK) Is a large cluster of L1 repeats at the Dlk1-Dio3 imprinted domain functional or junk?
16:10- 16:25 Robert FEIL  (IGMM and University of Montpellier, France) Loss of H3 lysine methylation and transcription of non-coding RNA pre-empt acquisition of DNA methylation imprints in male germ cells
Session X
Nuclear organisation and the inactive X (Chair: PHIL AVNER)
17:00 – 17:20 Matthias MERKENSCHLAGER  (MRC Clinical Sciences Centre, UK) Cohesin regulates gene expression and differentiation of mammalian cells independently of cell division
17:25 - 17:40 Erik SPLINTER  (Hubrecht Institute-KNAW & University Medical Center, Netherlands) The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA
17:45 - 18:05 Peter FRASER  (Babraham Institute, UK) High-resolution structure of the mouse X chromosome
18:10 - 18:25 Haruhiko KOSEKI  (RIKEN center for Allergy and Immunology, Japan) SAM domain-mediated polymerization of mammalian polyhomeotic homologues mediates recruitment of PRC1 to Polycomb target genes and their condensation
18:30 - 18:50 Edith HEARD  (Institut Curie, France) Epigenetic and nuclear dynamics during X-chromosome inactivation
18:55 - 19:05 Neil BROCKDORFF  (University of Oxford, UK) Meeting closure, concluding remarks, plans for XI meeting-4
19:30 - 20:00 Reception drinks
Sunday, July 24
  8:00 – 9:00 BREAKFAST


European Molecular Biology Organization | Meyerhofstrasse 1 | 69117 Heidelberg | Germany