Day 1 – Wednesday 5th May

2:00 pm

Welcome: Cliona O’Farrelly, Trinity College, Dublin

Session 1: Virus Replication and Host interactions

2:10– 3:10 pm

Keynote Address:

Induction and evasion of innate antiviral responses by hepatitis viruses
Stan Lemon, University of North Carolina at Chapel Hill, USA

3:10 – 3:50 pm

Hepatitis C Virus and the cell: an intricate relationship
Marco Binder, University of Heidelberg, Germany

A novel anti-viral role for STAT3 in IFN-α signalling, revealed by the Hepatitis C Virus;
Nigel Stevenson, Trinity College Dublin, Ireland

Coffee Break

4:40 – 5:20 pm

Quasispecies: Future proofing RNA viruses
Liam Fanning, University College Cork, Ireland

5:20 – 5:35 pm

Identification of interferon effectors that inhibit RNA virus replication
John Schoggins, The Rockefeller University, USA

5:35 – 6:15 pm

Sinusoidal endothelial cells regulates hepatocellular HCV replication
Jane McKeating, University of Birmingham, UK

6:15 – 8:30 pm

Poster Session and Welcome reception

Day 2 – Thursday 6th May

Session 2: PRRs and viruses (I)

 9:00 – 9:40 am

Toll-like receptor signaling and innate viral responses
Luke O’ Neill, Trinity College Dublin, Ireland

9:40 – 10:20 am

Intracellular DNA recognition by the innate immune system

Veit Hornung, University of Bonn, Germany

10:20 – 10:35 am

The G•U wobble base pair in secondary structure of single-stranded RNA is the cognate TLR7 ligand
Winfried Barchet, University of Bonn, Germany

10:35 – 10:50 am

The human DEAD-box protein 3 is targeted by vaccinia virus protein K7 to interfere with IRF3 activation and type I interferon production
Martina Schroeder, National University of Ireland Maynooth, Ireland,

Coffee Break

11:10 – 11:50 am

Viral-host interactions reveal novel anti-viral signalling proteins
Andrew Bowie, Trinity College Dublin, Ireland

11:50 – 12:05 pm

West Nile Virus non-structural protein 1 inhibits Toll-like receptor and TNF α signalling Joschka Willemsen, German Cancer Research Center, Germany

12:05 – 12:20 pm

Poly(I:C) activates p52 to induce Sp1 via IKKε
Sarah Doyle, Trinity College Dublin, Ireland

12:20 – 1:00 pm

Mapping innate immunity pathways using proteomics, viruses and PAMPS

Giulio Superti-Furga, Center for Molecular Medicine of the Austrian Academy of Sciences, Austria

LUNCH

Session 3: PRRs and viruses (II)

2:00 – 2:40 pm

Characterization of RIG-I agonists in virally infected cells
Jan Rehwinkel, Cancer Research UK, UK

2:40 – 2:55 pm

Identification of a novel poxviral viral inhibitor of interferon-β induction
Leonie Unterholzner, Trinity College Dublin, Ireland

2:55 – 3:10 pm

Varicella-Zoster Virus interferes with the innate immune response, by interfering with both NF-kB and IRF-3 signaling pathways
Catherine Sadzot-Delvaux, Laboratory of Virology & Immunology, Belgium

Coffee Break

3:40 – 3:55 pm

Equine arteritis virus nsp2 is a deubiquitinating enzyme with putative specificity for RIG-I; a novel viral immune evasion strategy?
Puck van Kasteren, Leiden University Medical Center, The Netherlands.

3:55 – 4:10 pm

Deregulation of inflammatory and anti-viral signalling by the Adenoviral E3-14.7K immunomodulatory protein
Andrew Macdonald, University of Leeds, UK

4:10 – 4:50 pm

New insights in RIG-I-mediated detection of viral

Gunther Hartmann, Bonn University, Germany

5:00 – 6 pm

Poster Session

Public Event 1:
The Fight Against Viruses: Reports from the Front
Selected short summaries by poster presenters.
Chaired by Ursula Weiss, Nature editor &

Nigel Stevenson, Trinity College Dublin

8 pm

Dinner: FIRE, Mansion House, Dawson Street

Day 3 – Friday 7th May

Session 4: NK cell activity against viral infection

9:00 – 9:40 am

Pathways for Allowing Flexibility in Cellular Responses to Viral Infection

Christine Biron, Brown University, USA

9:40 – 9:55 am

Phosphoantigen-stimulated Vγ9Vδ2 T cells promote Th1-biased adaptive immune responses and are differentially regulated in asymptomatic and symptomatic persistent hepatitis B virus infection;
Derek Doherty, Trinity College Dublin, Ireland

9:55 – 10:10 am

Host microRNA 199/214 function in murine and human cytomegalovirus infection: lessons from agonist-antagonist genome-wide screening

Amy Buck, University of Edinburgh, UK

Coffee Break

10:45 – 11:00 am

The kinetics of human natural killer cell activation in response to dsRNA virus infection in vivo; short and longer-lived responses?;

Graham Cook, University of Leeds, UK

11:00 - 11: 40 am

A role for NK cells in HCV infection.
Clair Gardiner, Trinity College Dublin, Ireland

11: 40– 12:20 pm

HCV, KIR, MHC and peptide

Salim Khakoo, Imperial College London, UK

LUNCH

Session 5: Innate-driven adaptive immunity against viruses

2:00 – 2:40 pm

Therapeutic vaccination with MVA: a novel application for the treatment of chronic hepatitis C
Genevieve Inchauspe, Department of Infectious Diseases, Transgene, France

2:40 – 2:55 pm

Multiple, distinct regulatory T cell populations control peripheral blood and liver immunity to human hepatitis C virus infections
Andre Boonstra, Erasmus MC, The Netherlands

2:55 – 3:10 pm

Virus-induced IL-6 is a potent co-factor for the pathogenesis of Theiler’s virus-induced demyelinating disease
Byung Kim, Northwestern University

3:10 – 3:45 pm

Innate signals that drive the induction and regulation of Th17 cells
Kingston Mills, Trinity College Dublin, Ireland

Coffee Break

4:15 – 4:50 pm

Innate immunity, dengue virus and vaccine development
Bruno Guy, Sanofi Pasteur, France

4:50 – 5:05 pm

Influenza infection significantly alters innate IL-23 and IL-12p70 and subsequent adaptive IL-17a responses to pneumococcus in humans

Sinead Loughran, Dublin City University, Ireland

5:05 – 5:45 pm

Prime-Boost Vaccination: with and against Viruses and Parasites

Adrian Hill, University of Oxford, UK

6pm

Public Event  2
Viral Infections: Past, Present & Future Challenges.

Prof. John Oxford, St Bart's and the Royal London and Retroscreen Virology Ltd.

Chaired by: Luke O’Neill, Trinity College Dublin