Programme
Dowload final programme: (pdf) |
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Saturday 27th March |
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12:00-14:50 |
Arrival and registration |
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14:50 -16:45 |
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Chairs: |
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14:50 - 15:00 |
Welcome Address |
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15:00 - 15:30 |
P. P. Thérond, IBDC, Nice, France Regulation of the Hedgehog long range activity in Drosophila. |
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15:30-16:00 |
S. Eaton, Max Planck Institute, Dresden, Germany Really long-range Hedgehog signaling. |
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16:00 - 16:30 |
H. Roelink, University of California, Berkeley, USA |
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16:30 - 16:45 |
B. Glise, CBD, Université Paul-Sabatier, Toulouse, France |
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16:45-17:30 |
Coffee break |
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17.30 - 19:00 |
Session 1 Continued |
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17:00-18:00 |
I. Guerrero, Universidad Autonoma de Madrid |
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18:00-18:30 |
S. Mayor, Tata Institute, Bangalore, India Hierarchical organization of Hh and its role in signaling. |
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18:30 - 19:00 |
T. Kornberg, UCSF, San Francisco, USA Mechanisms of morphogen dispersion and signal transduction. |
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| 19.30 | Dinner | |
21.00 - late |
COCKTAILS AND SOCIAL EVENT |
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| Sunday 28th March | ||
9.00 - 10.30 |
Secretion and Movement II |
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Chairs: |
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9:00-9:30 |
P. A. Beachy, Stanford University, Palo Alto, USA |
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9:30-10:00 |
J. Jiang, UT Southwestern Medical Center, Dallas, USA Kinase regulation of Smoothened signaling. |
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10:00 - 10:15 |
B. Allen, University of Michigan, Ann Arbor, USA Essential and opposing roles for cell surface Hh-binding proteins during mouse embryogenesis. |
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10:15 - 10:30 |
C. Siebold, University of Oxford, Oxford, United Kingdom Structural mechanism of hedgehog ligand sequestration by the human hedgehog-interacting protein Hip. |
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10.30 - 11:15 |
Coffee Break |
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| 11:15 - 12.045 | |
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| 11:15 - 11:45 | P. Mehlen, Centre Léon Bérard, Lyon, France SHH and the dependence receptor notion. |
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| 11:45 - 12:15 | A. Plessis, Jacques Monod Institute, Paris, France Dynamics and homeostasis of the Hedgehog receptor Patched: Regulation by E3 Ubiquitin ligases |
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12:15 - 12:30 |
A. Casali, IBMB-CSIC, Barcelona, Spain Self–induced Patched receptor degradation adjusts cell sensitivity to the Hedgehog morphogen gradient. |
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12:30 - 12:45 |
D. Leahy, Johns Hopkins University School of Medicine, Baltimore, USA Structure of the N-terminal protein domain of Dally-like protein. |
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12:45 14:00 |
LUNCH |
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| 14:00 - 16:00 | Free Time | |
16:00 - 17:00 |
Ligand reception and signal transduction II |
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Chairs: |
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16:00 - 16:30 |
X. Lin, Cincinnati Children's Hospital Cincinnati, USA Two cell-surface proteins Dally-like and Ihog differentially regulate Hh signalling strength and range during development. |
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16:30 - 16:45 |
K. Ayers, IDBC, Nice, France The glypican Dally and the hydrolase Notum regulate the switch between high and low level intracellular Hedgehog pathway signalling. |
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16:45 - 17:00 |
J. Filmus, Sunnybrook Research Institute, Toronto, Canada Glypican-5 stimulates rhabdomyosarcoma cell proliferation by activating hedgehog signaling. |
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17:00 - 17:45 |
Coffee Break |
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17:45 - 19:00 |
Session 3 continued |
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17:45 - 18:15 |
D. J. Robbins, University of Miami, Miami, USA Models of Hedgehog signaling. |
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18:15 - 18:30 |
B. Wang, Weill Cornell Medical College, New York, USA Suppressor of fused and SPOP regulate the stability and function of Gli2 and Gli3 full-length activators but not their repressors. |
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18:30 - 18:45 |
M.A. Price, Okinawa Institute of Science and Technology,Okinawa,Japan The mechanism of Ci repressor formation. |
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18:45 - 19:00 |
K. Nybakken, Boston Biomedical Research Inst., Boston, USA Regulation of Hh signaling by acetylation. |
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19:30 |
DINNER |
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21:00 |
POSTER SESSION I All Numbers |
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Monday 29th March |
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8:45 - 10:15 |
Hedgehog Signaling in Development and Regeneration I |
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Chairs: |
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8:45 - 9:15 |
J. Briscoe, NIMR, London, UK The gene regulatory logic for reading the sonic Hedgehog gradient in the vertebrate neural tube. |
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9:15 - 9:45 |
P. W. Ingham, IMCB, Singapore Cell fate specification in the zebrafish myotome: a paradigm for Hedgehog signalling activity. |
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9:45 - 10:15 |
A. P. McMahon, Harvard University, Cambridge, USA Exploring the regulatory network underlying HH-generated neural diversity. |
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10:15-11:00 |
Coffee Break |
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11:00-12:15 |
Session 4: Continued |
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11:00-11:30 |
C. Tickle, University of Dundee, UK Hedgehog signalling in vertebrate limb development. |
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11:30-12:00 |
E. Marti, CSIC, Barcelona, Spain Patterning and proliferation of neural progenitors cells requires integration of Wnt and Sonic hedgehog activities |
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12:00 - 12:15 |
C. Chiang, Vanderbildt University, Nashville, USA Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development. |
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12:15-13:45 |
LUNCH |
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13:45 - 16:30 |
OUTING: Villa Ephrussi de Rothschild museum and gardens |
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16:30 - 17:00 |
Coffee Break |
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17:00 - 18:00 |
Hedgehog Signaling in Development II |
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Chairs: James Briscoe, Cherryl Tickle |
17:00 - 17:30 |
F. Charron, IRCM, Montréal, Canada Wiring the brain: Hedgehog signaling and neural circuit formation. |
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17:30 - 18:00 |
M. Perron, Université Paris XI, Orsay, France Control of post-embryonic neurogenesis in the retina by a balance between Hedgehog and Wnt signaling pathways |
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18:00 - 20:00 |
POSTER SESSION II (odd numbers) |
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20:00 |
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Tuesday 30th March |
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8:45-10:15 |
Hedgehog and Primary Cilia I |
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Chairs: Alexandra Joyner, Jeremy Reiter |
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8:45-9:15 |
K. Anderson, Sloan-Kettering Institute, Cambridge, USA Cilia and Hedgehog signaling in the mouse embryo |
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9:15-9:45 |
P.-T. Chuang, UCSF, San Francisco, USA Cilium-dependent and -independent processes in mammalian Hedgehog signaling. |
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9:45-10:00 |
L. Milenkovic, Stanford University, Palo Alto, USA Tracing Smoothened to the primary cilium |
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10:00-10:15 |
M. Bijlsma, University of California, Berkeley, USA Ciliary function is not required for non-canonical Hedgehog signal transduction. |
10:15-11:00 |
Coffee Break |
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11:00-12:00 |
Session 6: Continued |
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11.00-11.30 |
J. Reiter, UCSF, San Francisco, USA Primary cilia can both mediate and suppress Hedgehog pathway–dependent tumorigenesis. |
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11:30-11:45 |
J. Eggenschweiler, Princeton University, Princeton, USA Broad-minded links ciliary assembly, cell cycle-related kinase function, and mammalian Hedgehog signaling. |
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11:45 - 12:00 |
S. Schneider-Maunoury, CNRS UMR7622, Paris, France Disruption of the ciliary gene Ftm/Rpgrip1l causes telencephalic patterning and morphogenesis defects by preventing the formation of Gli3R. |
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12:00-14:00 |
LUNCH |
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| 14:00 - 15:00 | FREE TIME | |
15:00-16:15 |
Hedgehog in Cancer and Cancer Stem Cells I Brain Tumorigenesis |
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Chairs: Kathryn Anderson, Rune Toftgård |
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15:00-15:30 |
A. Gulino, University La Sapienza, Rome, Italy Regulation of Hedgehog/Gli function in cerebellar stem/progenitor and medulloblastoma cells |
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15:30 - 16:00 |
A. Ruiz i Altaba, University of Geneva, Geneva, Switzerland The GLI code in cancer stem cells. |
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16:00 - 16:15 |
A. Kenney, MSKCC, New York, USA Sonic Hedgehog: Hippo pathway cross-talk in neural precursor proliferation and pediatric brain tumorigenesis. |
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16:15-16:45 |
Coffee Break |
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16:45-18:15 |
Session 7: continued |
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16:45 - 17:15 |
A. L. Joyner, Sloan-Kettering Cancer Center, New York, USA Gli1 as a tool to study skin homeostasis, wound repair, and cancer. |
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17:15 - 17:45 |
M. P. Scott, Stanford University, Palo Alto, USA Target gene regulation by Gli1. |
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17:45-18:15 |
F. Aberger, University of Salzburg, Salzburg, Austria Cooperative Hedgehog/GLI signaling in cancer |
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18:15 - 20:15 |
POSTER SESSION III Even Numbers |
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20:30 |
DINNER |
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Wednesday 31th March |
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8:45 - 10:15 |
Hedgehog in Cancer and Cancer Stem Cells II Skin and other tumors |
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Chairs: Alberto Gulino, Ariel Ruiz Altaba |
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08:45 - 09:15 |
R. Toftgård, Karolinska Institute,Huddinge, Sweden |
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9:15 - 9:45 |
A. Oro, Stanford University, Palo Alto, USA Dermal requirements for sonic Hedgehog signaling during hair follicle morphogenesis. |
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9:45 - 10:00 |
B. Stecca, Istituto Toscano Tumori, Florence, Italy Hedgehog-GLI signaling is essential for melanoma stem cell survival. |
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10:00 - 10:15 |
J. Sage, Stanford, Palo Alto, USA Cell-autonomous role for Hedgehog signaling in small cell lung carcinoma. |
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10:15-11:00 |
Coffee Break |
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11:00-12:15 |
Hedgehog in Cancer and Cancer Stem Cells III Clinical trials |
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Chairs: Frederic de Sauvage, Isabel Guerrero |
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11:00-11:30 |
F. de Sauvage, Genentech Inc, San Francisco, USA Targeting the Hedgehog pathway in cancer. |
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11:30-11:45 |
K. McGovern, Infinity Pharmaceuticals, Cambridge, USA Activity of a Smoothened inhibitor, IPI-926, in ligand-dependent and ligand-independent tumors. |
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11:45 - 12:00 |
K. Bennett, Bristol-Myers Squibb, Lawrenceville, USA Characterization of BMS-833923 (XL139), a Hedgehog (HH) pathway inhibitor in early clinical development. |
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| 12:00 - 12:15 | S. Buonamici, Novartis, Cambridge, USA Resistance to smoothened antagonists can be abrogated by PI3K pathway inhibition. |
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12:30 |
END OF THE MEETING |
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12:30-14:00 |
LUNCH AND DEPARTURE |
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