Programme
Download Programme (word.doc) |
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Wednesday,
September 1st
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13:00
– 17:00
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Registration
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17:00
– 18:00
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Opening
Mixer
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18:00
– 19:10
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Opening
Session |
18:00
– 18:10
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Opening
remarks
|
18:10
– 19:10
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Keynote
lecture:
Wade
Harper
Proteomic
exploration of the ubiquitin system
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19:15
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Dinner
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Thursday,
September 2nd
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8:30
– 10:40
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Ubiquitin family and genome stability (I) |
8:30
– 9:00
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Titia Sixma
Protein-protein
interactions modulating ubiquitin conjugation
|
9:00
– 9:30
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Ivan Dikic
Ubiquitin binding domains in DNA repair pathways
|
9:30
– 10:00
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Ashok Venkitaraman
Protein ubiquitylation in the control of chromosome
stability
|
10:00
– 10:20
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Tomohiko Ohta
Recruitment
of phosphorylated NPM1 to sites of DNA damage
through RNF8-dependent ubiquitin conjugates
|
10:20
– 10:40
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Kristijan Ramadan
Ubiquitin dependent molecular chaperone p97/VCP is a crucial component in the
cellular response to genotoxic stress
|
10:40
– 11:10
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Coffee
Break
|
11:10
– 13:30
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Ubiquitin family and genome stability (II) |
11:10
– 11:40
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Jesper Q. Svejstrup A ubiquitin-binding domain in Cockayne syndrome B required fortranscription-coupled repair |
11:40
– 12:10
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Vishva Dixit
A Ubiquitin hydrolase that promotes oncogenic transformation by
stabilizing Cdc25A
|
12:10
– 12:40
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Roger
A. Greenberg
ATM
dependent ubiquitination influences
transcription at chromatin contiguous to DNA double strand
breaks
|
12:40
– 13:10
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Xiaolan Zhao
SUMO's influence at the ends of chromosomes
|
13:10
– 13:30
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Tony
Huang
Regulation
of the DUB USP1 by Proteolysis
|
13:30
– 16:00
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Lunch
and free time
|
16:00
– 17:30
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Poster
Session I
|
17:30
– 19:30
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The Fanconi anemia
pathway
Chair:
Daniel Durocher
|
17:30
– 18:00
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Arno Alpi
The
E2 conjugating enzyme Ube2t: Ubiquitin signalling in the Fanconi anaemia pathway and nucleotide excision
repair
|
18:00
– 18:30
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Helen
Walden
Insights
into the catalytic core of the Fanconi anemia
pathway
|
18:30
– 19:00
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Alan D’Andrea
Regulation
of the Fanconi anemia pathway by ubiquitination and sumoylation
|
19:00
– 19:30
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Agata Smogorzewska
New
proteins in the Fanconi anemia
pathway
|
20:00
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Dinner
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Friday,
September 3rd
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8:30
– 10:40
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The
DSB response: signal transduction and chromatin reorganization
(I)
Chair: Karlene Cimprich
|
8:30
– 9:00
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Jiri
Lukas
Spatio-temporal
organization of the DNA damage response by ubiquitin signaling and chromatin
remodeling.
|
9:00
– 9:30
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Junjie Chen
Regulation
of DNA repair via ubiquitination-dependent
signaling pathways
|
9:30
– 10:00
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Steve
Jackson
Cellular
responses to DNA damage in the context of
chromatin
|
10:00
– 10:20
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Niels Mailand
SUMOylation of HERC2 regulates protein assembly at DNA double-strand break
sites
|
10:20
– 10:40
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Jo
Morris
Small
modifiers and BRCA1
|
10:40
– 11:10
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Coffee
break
|
11:10
– 13:10
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The
DSB response: signal transduction and chromatin reorganization
(II)
Chair: Alan
Lehmann
|
11:10
– 11:40
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Daniel
Durocher
Regulation
of RNF8-RNF168 dependent signaling
|
11:40
– 12:10
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Exploration
of the interface between the ubiquitin and DNA
damage response arenas
|
12:10
– 12:30
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RNF4,
A SUMO targeted E3 ubiquitin ligase, is a novel regulator of the DNA damage
response
|
12:30
– 12:50
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Ciaran Morrison
Functional
dissection of the Smc5/6 complex by reverse
genetics
|
12:50
– 13:10
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Haico van Attikum
The
SMARCA5/SNF2h chromatin remodeler regulates BRCA1 and BRCA2 responses to
DNA double-strand breaks
|
13:10
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Light
lunch
|
14:00
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Tour
of the
Dinner
included; expected return around 23:00
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Saturday,
September 4th
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|
8:30
– 10:50
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Damage
tolerance
Chair: Junjie Chen
|
8:30
– 9:00
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Helle
Ulrich
Timing
and spacing of ubiquitin-dependent DNA damage
bypass
|
9:00
– 9:30
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Fumio
Hanaoka
Regulation
of translesion DNA synthesis with special
emphasis on DNA polymerase eta and PCNA ubiquitylation
|
9:30
– 10:00
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Stefan Jentsch
Mechanisms
and timing of the RAD6 DNA damage tolerance
pathway
|
10:00
– 10:30
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Alan
Lehmann
The
role of ubiquitination in translesion synthesis by DNA
polymerase
eta
and nucleotide excision repair synthesis by DNA polymerase
kappa
|
10:30
– 10:50
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Anja Bielinsky
DNA
damage recognition and PCNA ubiquitination during lagging strand synthesis
|
10:50
– 11:20
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Coffee
break
|
11:20
– 13:30
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Cell
cycle dynamics, implication for cancer formation
(I)
Chair: Titia Sixma
|
11:20
– 12:10
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Jiri
Bartek
The ubiquitin family in DNA damage signaling, tumorigenesis, and cancer
treatment
|
12:10
– 12:40
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Carol Prives
Regulation
of the p53 regulators, Mdm2 and MdmX
|
12:40
– 13:10
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Moshe
Oren
RNF20
and H2B ubiquitylation: a cancer
link
|
13:10
– 13:30
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Olivier Coux
Cross-talks
between ubiquitylation and acetylation in the regulation of
p53
|
13:30
– 15:30
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Lunch
and free time
|
15:30
– 17:00
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Poster
session II
|
17:00
– 19:50
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Cell
cycle dynamics, implications for cancer formation
(II)
Chair: Jiri
Bartek
|
17:00
– 17:30
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Jiandong Chen
MDM2 phosphorylation and DNA damage signaling to
p53
|
17:30
– 18:00
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Kevin Hiom
Understanding
the function of the BRCA1 ubiquitin ligase
|
18:00
– 18:30
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Michele Pagano
Regulation
of the DNA damage response by SCF ubiquitin ligases
|
18:30
– 19:00
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Dina Raveh
The
role of the DDR in ubiquitin-mediated
degradation of the yeast mating switch endonuclease
|
19:00
– 19:30
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Matthias
Peter
Regulation
of DNA-replication and mitosis by cullin-based
E3-ubiquitin ligases
|
19:30
– 19:50
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Xiaochun Yu
RNF8
and Chfr synergistically maintain genomic
instability and suppress tumorigenesis
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20:00
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Dinner
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Sunday,
September 5th
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8:30
– 10:30
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Nucleotide
excision repair, postreplication repair, the RecQ helicases
Chair: Agata Smogorzewska
|
8:30
– 9:00
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Dana Branzei SUMO protease-mediated regulation of chromosome integrity |
9:00
– 9:30
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Karlene Cimprich
Post-replication
repair: A tale of two ubiquitin ligases
|
9:30
– 9:50
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Jurgen Marteijn
The
role of the ubiquitin proteasome system in the UV induced DNA damage
response
|
9:50
– 10:10
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Nathan
Ellis
BLM SUMOylation regulates RAD51 and RPA–ssDNA levels at stalled
forks
|
10:10
– 10:30
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Rikke Frøhlich Hougaard
Regulation
of WRN function and activity by sumoylation during the DNA damage response
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10:30
– 10:50
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Coffee
break
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10:50
– 12:20
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Damage
recognition, host-virus interactions
Chair:
Ivan Dikic
|
10:50
– 11:10
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Shunichi
Takeda
Differential
functional interactions between the RNF8 and RAD18 E3 ubiquitin ligases in translesion DNA synthesis and DSB
repair
|
11:10
– 11:30
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Nicolas Thoma
Structural
basis of UV-damage recognition and ubiquitination by the DDB1/2-Cul4
complex
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11:30
– 11:50
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Matthew
Weitzman
Viral
manipulation of ubiquitination to control DNA
damage responses and intrinsic host
defenses
|
11:50
– 12:10
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Anindya Dutta
Cellular
and viral ubiquitin ligase pathways that modulate the cell’s response to
DNA damage
|
12:10
– 12:20
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Concluding
remarks
|
12:20
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Lunch
and farewell
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