Workshop

European Molecular Biology Organization


RUNX Transcription Factors in

Development & Disease

 

 

 

 

 


16 - 19 August| 2009 |Oxford| United Kingdom

Programme

 

Sunday 16th  | Monday 17th  |  Tuesday 18th  |  Wednesday 19th

     
Download Programme:  (word.doc)
   

Sunday August 16

 

  

From 12.00    

CHECK-IN 

 

12.00-17.30    

REGISTRATION

  

 

 

  

16.30-17.30    

WELCOME RECEPTION

  

17.30-19.00    

DINNER

  

 

 

 a

19.00-21.40

EVENING SESSION 1

  

                       

 

  

19.00-19.10    

Opening of meeting

 Chairpersons: Nancy Speck, Yoram Groner

  

 

I. Runx proteins in development and homeostasis of epithelia and associated immune cells 

 

 

 

  

19.10-19.30

Roger Patient (Weatherall Institute of Molecular Medicine, Oxford, UK)

Runx1 and CBFβ play distinct roles during the emergence of haematopoietic stem cells in the dorsal aorta		  

19.30 - 19.50                    

Georges Lacaud (Paterson Institute for Cancer Research, Manchester, UK)

The differential transcriptional activities of Runx1 promoters define milestones during embryonic hematopoiesis		  

19.50 - 20.00

Marella de Bruijn (Weatherall Institute of Molecular Medicine,Oxford, UK)
Short talk
Non-redundant functions for Runx1 alternative promoters at the onset of Mouse definitive hematopoiesis

 a
20.00 - 20.10

Cherry Ng (Osato lab, Cancer Science Institute, National University of Singapore, Singapore)
Short talk

An intronic Runx1 enhancer marks hematopoietic stem cells		  
20.10 - 20.40 Coffee Break  
     
 

II.  Runx transcriptional networks in non-mammalian development

  

20.40 - 21,00

Uri Gat (Hebrew University, Jerusalem, Israel)

The evolution of the Runx factor network:  Insights from the study of a basal progenitor in the sea anemone Nematostella		  

21.00 - 21.20          

James Coffman (Mount Desert Island Biological Laboratory, Maine, USA)

The Runx-regulated transcriptome of blastula stage sea urchin embryos		  

21.20 - 21.40

Lisa Prazak (Gergen lab, Department of Biochemistry and Cell Biology,
Stony Brook, NY, USA)
Functional dissection of a Runt response element in the Drosophila blastoderm embryo

  

21:40

 St Anne’s cash bar open

 a

 

 

  
Monday 17th, August    
08.00 - 09.00 Breakfast  
09.00 - 12.20

MORNING SESSION 1

                   Chairpersons: Jim Neil, Stephen Nimer   		 
 

I. Runx proteins in development and homeostasis of epithelia and associated immune cells 

 

09.00-09.20

Yoshiaki Ito (Cancer Science Institute Singapore, Institute of Molecular and Cell Biology, Singapore)
Roles of RUNX3 in gastrointestinal tract cancers

 

09.20-09.30

Kosei Ito (Graduate School of Biomedical Sciences, Nagasaki University, Japan)                      
Short talk
Runx3 attenuates oncogenic Wnt signaling that upregulates Cdx2 in gastric epithelial cells

 

09.30-09.50

Ditsa Levanon (Groner lab, Weizmann Institute of Science, Rehovot, Israel)
New insights into the mechanism of inflammatory bowel disease (IBD) etiology in Runx3-deficient mice

 

09.50-10.10

Ichiro Taniuchi (Yokohama, Kanagawa, RIKEN Research Center for Allergy and Immunology, Japan)
Essential requirement of Cbfb2 variant for Smad4-mediated TGFb signals and for development and homeostasis of immune system

 

10.10-10.20

Boris Ratsch (Hamann lab, Exp. Rheumatology, Charité Berlin, Germany)
Short talk
Runx transcription factors control the expression of skin-homing receptors in CD4+ T cells

 

10.20-10.50

COFFEE BREAK

 
 

II.  Runx proteins in development and homeostasis of the breast

  

10.50-11.00

Eli Raveh (Gat lab, The Hebrew University of Jerusalem, Jerusalem,Israel)
Short talk
Runx1 in mammary gland development – Expression pattern and a possible branching deficiency in a myoepithelial targeted knockoutmodel

 

11.00-11.20    

Matthew Naylor (Garvan Institute of Medical Research, Darlinghurst, Australia)
The osteogenic transcription factor Runx2 is essential for mammary gland development

 

11.20-11.40

Karen Blyth (Beatson Institute of Cancer Research, Glasgow, UK)
Transgenic Runx2 expression causes pre-neoplastic changes in mammary epithelium

 

 

 

 

 

 

 

 

 

 

 

 

 

III.  Runx proteins in development of the nervous system

  

11.40-12.00

Stefano Stifani (McGill University, Montreal, Canada)
Involvement of Runx1 in mammalian nervous system development:  Neurogenesis and more

 

12.00-12.20

Joriene de Nooij (Jessell lab, Columbia University, New York, USA)
Molecular pathways of proprioceptive sensory neuron differentiation

 

13.00-14.00                           

LUNCH

 

14.00-16.00  

NETWORKING

 

16.00-18.00                           

POSTER-SESSION

 

18.00-19.30                           

DINNER

 
19.30 - 22.00

EVENING SESSION 2
Chairpersons: Gary Stein, Dong-Er Zhang

  
 

I.  Runx proteins in bone development

  

19.30-19.50

Alexander Medvinsky (MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, University of Edinburgh, Edinburgh, UK)
The non-redundant role of Runx1 in skeletal development

 

19.50-20.10    

Andre van Wijnen (University of Massachusetts Medical School, Worcester, USA)
The osteogenic transcription factor Runx2 regulates components of the fibroblast growth factor/proteoglycan signaling axis in osteoblasts

 

20.10-20.30

Toshihisa Komori (Nagasaki University, Japan)
Runx2 inhibits terminal differentiation of odontoblasts and induces transdifferentiation of odontoblasts into osteoblasts

 

20.30-20.50                           

COFFEE BREAK

 
 

II.  Runx proteins in leukemia and as therapy targets (Co-sponsored by the LRF)

  

20.50-21.10

Dong-Er Zhang (University of California San Diego, USA)
Molecular targets of t(8;21) fusion proteins in leukemia development

 

21.10-21.30

Lucas Waltzer (CNRS UMR5547 Centre de Biologie du Développement, Toulouse, France)
An in vivo RNAi screen in Drosophila identifies modulators of the human leukaemogenic fusion protein RUNX1-ETO

 

21.30-21.40

Christian Wichmann (Grez lab, Georg-Speyer-Haus, Institute for Biomedical Research, Frankfurt, Germany)
Short talk
Interference with RUNX1/ETO leukemogenic function by peptides targeting the oligomerization domain

 

21.40-22.00

John Bushweller (University of Virginia, Charlottesville, USA)
Development of small molecule inhibitors of CBF fusion proteins

 

22.00                                      

St Anne’s cash bar open

 

Tuesday 18 August

 

 a

 

 

  

08.00-9.00

Breakfast

 

 

 

  

09.00-12.20

MORNING SESSION 2

  

                       

Chairpersons: Karen Blyth, Andrew van Wijnen             

 

                       

 

 a

 

I.  Runx proteins in proliferation and differentiation

  

 

 

  

09.00-09.20

Alison Woollard (University of Oxford, Oxford, UK)
Regulating C. elegans stem cell divisions in time and space: The role of Runx/CBFb

a

09.20-09.40

Motomi Osato (Cancer Science Institute of Singapore, National University of Singapore, Singapore)
Runx, niche, and stem cell quiescence

 

09.40-10.00

Nancy Speck (University of Pennsylvania School of Medicine, Philadelphia, USA)
Loss of Necdin expression contributes to decreased quiescence of Runx1 deficient hematopoietic stem cells

 

10.00-10.20    

Anna Kilbey (Neil lab, Institute of Comparative Medicine, Glasgow, UK)
Direct regulation of sphingolipid metabolism and signaling by the Runx family

 

10.20-10.40

Suk-Chul Bae (Chungbuk National University, Cheongju, South Korea)
The Runt-related transcription factor RUNX3 is a target of MDM2-mediated ubiquitination

 

10.40-11.10                           

COFFEE BREAK

 

11.10-11.30

Claus Nerlov (Institute for Stem Cell Biology, University of Edinburgh, Edinburgh, UK)
Runx1 protein-protein interactions during the switch from proliferation to differentiation

 

11.30-11.50    

Alan Friedman (Johns Hopkins University, Baltimore, USA)
RUNX1 regulates hematopoietic proliferation and myeloid differentiation

a

11.50-12.10

Adam Goldfarb (University of Virginia School of Medicine, Charlottesville, Virginia, USA)
Characterization of a megakaryocytic regulatory circuit comprising GATA-1, RUNX1, and P-TEFb

 

12.10-12.20    

Boet van Riel (Grosveld lab, ErasmusMC, Rotterdam, The Netherlands)
Short talk
Protein complex and target gene identification of Runx1 in erythroid cells

 

12.20-12.40

Jennifer Westendorf (Mayo Clinic, Rochester, MN, United States)
Coactivator activator (CoAA) prevents the transcriptional activity of Runt domain transcription factor

 

13.00-14.00  

LUNCH

 

14.30 - 17.20

AFTERNOON SESSION 1   
Chairpersons: Lucio Castilla, Ichiro Taniuchi

 

 

I.  Runx proteins in epigenetic and microRNA-mediated gene regulation

a

14.30-14.50

Gary Stein (University of Massachusetts Medical School, Worcester, USA)
Runx-mediated epigenetic regulation of cell growth and phenotype for biological control and cancer

a

14.50-15.10

Constanze Bonifer (Leeds Institute of Molecular Medicine, University of Leeds, UK)
Chromatin unfolding by Runx1 in hemangioblasts – a molecular  explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program

 

15.10-15.20

Gang Huang (Cincinnati Children's Hospital Medical Center, Cincinnati, USA)
Short talk
Differential MLL interaction and H3K4me3 mark maintenance at PU.1 regulatory region - an epigenitic aspect of CBF related leukemogenic molecules

 

15.20-15.40

Issay Kitabayashi (National Cancer Center Research Institute, Tokyo, Japan)
Roles of histone acetyltransferases MOZ/MORF in hematopoiesis and leukemia

 

15.40-15.50

Janice Telfer (University of Massachusetts Amherst, Amherst, USA)
Short talk
RUNX and lysine modifcations in CD4 silencing

 

15.50-16.20                           

COFFEE BREAK

a

16.20-16.40

Yoram Groner (The Weizmann Institue of Science, Rehovot, Isreal)
A regulatory interplay between RUNX1 and miR-27a during megakaryopoiesis

 

16.40-17.00    

Clara Nervi (University of Rome, "La Sapienza", Rome, Italy)
Epigenetic regulation of microRNA-223 in normal and leukemic myelopoiesis

 

17.00-17.20

Lucio Castilla (University of Massachusetts Medical School, Worcester, USA)
Role of microRNA cluster miR17-92 in CBFb-MYH11 acute myeloid leukemia

 

18.00

GUIDED WALK THROUGH OXFORD TO ORIEL COLLEGE
(If you miss the walking tour, please make your way to Oriel College in time for the Group Photo at 7pm – approx 15/20 min walk, map in delegate pack)

 

19.00

GROUP PHOTO

 

 

 

 

19.15-22.00  

BANQUET AT ORIEL COLLEGE

 

 

 

 

22.00                                      

Oriel cash bar open until midnight

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Wednesday 19 August

 

 a

 

 

  

08.00-9.00

Breakfast

  

 

 

  

09.00-13.00

MORNING SESSION 3

  

                               

Chairpersons: Carol Stocking, Mineo Kurokawa

  

           

 

  

 

I.  Runx proteins in leukemia /lymphoma 

 

 

 

  

09.00-09.20

Stephen Nimer (Memorial Sloan Kettering Cancer Center, New York, USA)

Interaction of RUNX1 and RUNX1-ETO with histone modifying enzymes regulates their functional properties		 a

09.20-09.40

Masahiro Nakagawa (Kurokawa lab, Department of Hematology &
Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan)
Critical regulation of Nf-kB signaling by AML1/RUNX1 in normaland malignant hematopoietic cell

  

09.40-09.50

Rhys Morgan (Darley lab, Cardiff University, Cardiff, UK)
Short talk

The role of g-catenin in acute myeloid leukaemia		  

09.50-10.10         

Ewan Cameron (University of Glasgow, Glasgow, United Kingdom)
TEL-RUNX1 confers lineage specific effects on haematopoietic progenitors

 
 

10.10-10.30         

Gareth Brady (Farrell lab, Imperial College London, London, UK)

Functional differences between RUNX1, RUNX3 and RUNX fusion genes in EBV-infected human B cells		 a

10.30-11.00

COFFEE BREAK   

 

11.00-11.10

Kimiko Shimizu (Kitabayashi lab, National Cancer Center Research Institute, Tokyo, Japan)
Short talk
Hemizygosity of AML1/RUNX1 prevents T-cell malignancyinduced by loss of p53

  

11.10-11.30         

Hironori Harada (Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan)

Two different AML1 mutants expressed in human CD34+ cells exhibit distinct molecular pathways and clinical features of MDS/AML		  

11.30-11.50

James Mulloy (Cincinnati Children's Hospital, Cincinnati, USA)

Survival signalling in t(8;21) leukemia

 a

11.50-12.10

Christopher Klug (The University of Alabama at Birmingham, Birmingham, AL, USA)
Defining leukemia-initiating cells and cooperating pathways in development of core-binding factor-associated acute myeloid leukemia

  

12.10-12.30

Paul Liu (NIH, Bethesda, MD, USA)

c-Kit mutations D816Y/V cooperate with CBFB-MYH11 to accelerate leukemogenesis in mice            		 

12.30-13.00

SUMMARY AND HIGHLIGHTS OF THE MEETING

 

13.00-14.00

LUNCH

  

14.00-19.00         

OPTIONAL: POST-CONFERENCE TOUR TO ROUSHAM PARK

Bus leaves from the porter’s lodge at 14.00 hrs

 

 

 




 

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