9:10 - 9:15

Opening remarks: François Guillemot

Session 1:           

cancer and stem cells I

(chair: Ryoichiro Kageyama)

09:15: 09:45

Antonio Iavarone (Columbia University, New York)
Post-translational regulation and function of Id proteins in cell cycle and cancer

09:45 - 10:15

Chuck Stiles (Dana Farber Cancer Institute, Boston)
Olig Transcription Factors in Development and Disease 

10:15 - 10:45

Bruno Amati (European Institute of Oncology, Milan)
Cdk2 suppresses cellular senescence induced by myc or wnt oncogenes: a new rationale for targeting a cyclin-dependent kinase in cancer

10:45 - 11:15

11:15 - 11:45

Kees Murre (University of California, San Diego)

Regulation and function of E-proteins in lymphocyte development and cancer

11:45 - 12:15

Robert Benezra (Sloan-Kettering Institute, New York)
Control of stem cell fate by the Id proteins

12:15 - 12:30

Lindy Barrett (Sloan-Kettering Institute, New York)
The role of Id proteins in glioblastoma multiforme (GBM) tumorigenesis

12:30 – 13:00

Harry Heimberg (Vrije Universiteit Brussel)
Neurogenin 3, a tool for reprogramming and tracing

13:00 - 15:30

15:30 - 16:00

Session 2

bHLH factors in cell fate decisions

(chair: Steve Tapscott)

16:00 - 16:30  

Yuan Zhuang (Duke University, Durham)
Cessation of E-protein expression is both necessary and sufficient to unleash a default developmental pathway leading to CD8 T lymphocyte development

16:30 - 17:00

Jane Johnson (University of Texas, Dallas)
PTF1-J: A Unique bHLH Factor-Transcription Complex Required for Neuronal Specification

17:00 - 17:30

Sharagim Tajbakhsh (Institut Pasteur, Paris)

Distinct regulatory cascades govern extraocular and branchiomeric muscle progenitor cell fates

17:30 - 17:45

Patricia Hornitschek (University of Lausanne)

HFR1 negatively regulates the shade avoidance response by preventing PIF4 and PIF5 DNA binding

17:45 - 19:00

Friday 8th May

Session 3

Regulation of bHLH factors

(chair: Antonio Iavarone)

09:00 - 09:30

Dominique Bergmann (Stanford University)

09:30 - 10:00

Mary Baylies (Sloan-Kettering Institute, New York)

Twist activity is regulated by concentration, dimer partner, tissue context and developmental timing during Drosophila myogenesis

10:00 - 10:15

Thomas Grundström (Umea University)
Calmodulin inhibition of E-proteins in initiation of antigen dependent differentiation to plasma cells

10:15 - 10:45

10:45 - 11:15

Ryoichiro Kageyama (Kyoto University)
The role of Hes1 in proliferation and differentiation of neural stem cells

11:15 - 11:30

Isabel Palmeirim (University of Minho, Braga)
Cyclic expression of a bHLH gene reveals a molecular clock operating during chick limb bud outgrowth and patterning

11:30 - 11:45

Nick Monk (University of Nottingham)
Dissecting the dynamics of Notch pathway oscillations

11:45 - 12:15

Anna Philpott (University of Cambridge)
Neurogenin has a short half-life and is targeted for proteasomal degradation by ubiquitination on canonical and non-canonical residues.

12:15 - 14:45

14:45 - 15:15

Session 4:          

Downstream transcriptional programs

(chair: Kees Murre)

15:15 - 15:45

Andrew Jarman (University of Edinburgh)
Regulation and function of proneural factors in Drosophila sensory neurogenesis

15:45 - 16:15

Francois Guillemot (National Institute for Medical Research, London) 
Two bHLH-Rho protein pathways with divergent roles in neuronal migration

Kristen Kroll (Washington University, St Louis)
Transcriptional and epigenetic regulation of neuronal commitment and differentiation

16:45 - 17:00

Diogo Castro (National Institute for Medical Research, London)
Characterization of the neurogenic program regulated by the vertebrate proneural factor Mash1 by genomic location analyses

17:00 - 17:30

17:30 - 18:00

Stephen Tapscott (Fred Hutchinson Cancer Research Center, Seattle)
Regulation of skeletal muscle gene expression by MyoD in normal development and disease

18:00 - 18:15

Manfred Gessler  (University of Würsburg)
Identification of novel target genes for Hey bHLH transcription factors

18:15 - 18:45

Bertold Gottgens (University of Cambridge)
The Transcriptional Programme Controlled by the Stem Cell Leukaemia Gene Scl/Tal1 during Early Embryonic Blood Stem Cell Development

18:45 - 19:00

Catherine Porcher (University of Oxford)
Phenotypic and genome-wide molecular analyses reveal in vivo requirements for SCL direct and indirect DNA-binding activity

19:00 - 19:10  

Closing remarks

by Robert Benezra