Workshop

14.30-15:50

Registration

15:50 - 16:00

Welcome address

16.15-18.15

Session 1 “Identification of stem cells in normal and cancer tissues”

Chairperson: Kari Alitalo

16.00 - 16.40

John Stingl (Cancer Research UK, Cambridge, UK)
Deciphering the mammary epithelial cell hierarchy

Nicolas Wright (Bart’s and the London School of Medicine, London, UK)
Gut stem cells

Ruggero De Maria (Istituto Superiore di Sanita', Rome, Italy)

Colon cancer stem cells

  Christine Chaffer (Whitehead Institute for Biomedical Research, Cambridge, USA)

Spontaneous generation of stem-like cells from normal and transformed human mammary epithelial cel

Patrick Viatour (Stanford University, Palo Alto, USA)
Cellular and molecular mechanisms of hepatocellular carcinoma initiation upon the loss of the retinoblastoma family of genes

19:00

Venue: Aula Magna Rettorato University of Torino
Welcome Cocktails

Friday September 11th, 2009
Venue: Centro Congressi Torino Incontra

09.30 – 12.00

Session 2 “Cancer stem cells as a target for tumour therapy”

09.30 - 10.10

Luigi Naldini (TIGET-HRS, Milan, Italy)
Stem-cell based anti-angiogenic therapy

10.10 - 10.50

Jeremy Rich (Cleveland Clinic, Cleveland, USA)

Cancer stem cell radioresistance

11.05 - 11.45

Catriona Jamieson (Moores UCSD Cancer Center, La Jolla, USA)

Targeting cancer stem cells

11:45 -12:00

Marc de la Roche (MRC Laboratory of Molecular Biology, Cambridge, UK)
A small molecule inhibitor of the oncogenic Wnt signalling pathway

12.00 - 13.00

Lectio Magistralis (Joint SIAI – EMBO)
Günter Blobel (Rockefeller University, New York, USA)
The nuclear pore complex as the gate keeper for traffic into and out of the nucleus

Lunch

14:10 - 15:40

Poster Session

15.40 - 18.40

Session 3/I “Cancer/stem cell mobilization and metastasis”

15.40 - 16.20

Carl Henrik Heldin (Ludwig Institute for Cancer Research, Uppsala, Sweden)
TGF-beta and PDGF signals controlling cell mobilization/invasion

Thomas Brabletz (University Medical Center, Freiburg, Germany)

Migrating cancer stem cells

Paolo Comoglio (IRCC, University of Turin, Italy)

MET, invasive growth and stem cells

Stéphanie Kermorgant (Institute of Cancer, London, UK)
A direct role for c-Met endocytosis in cell migration and tumorigenesis

Christina Scheel (Whitehead Institute for Biomedical Research, Cambridge, USA)
Autocrine signaling induced by Epithelial-Mesenchymal Transition in the context of breast cancer

19:30

Venue Palazzo Madama, Torino

Saturday September 12th, 2009

Venue: Centro Congressi Torino Incontra

09.30-11.05

Session 3/II “Cancer/stem cell mobilization and metastasis”

09.30 - 10.10

Walter Birchmeier (Max Delbruck Centre for Molecular Medicine, Berlin, Germany)
Developmental signalling pathways in cancer stem cells and metastatic cells

10.10 - 10.50

Christopher Heeschen (Spanish National Cancer Institute–CNIO, Madrid, Spain)

Pancreatic tumor stem cells and metastasis

Francesca Orzan (Istituto Neurologico C. Besta, Milan, Italy)
Enhancer of Zeste 2 is a relevant gene for cancer stem cells and glioma progression

11:30 - 13:00

13:10 - 14:20

14.20-18.00

Session 4 “Signalling for stem cell self-renewal”

14.20 - 15.00

Pier Giuseppe Pelicci (IFOM-IEO, Milan, Italy)
Self-renewal of leukaemia stem cells

15.00 - 15.40

Hannele Ruohola-Baker (Institute Stem Cells and Regenerative Medicine, Seattle, USA)
miRNA and stem cells

15.40 - 15.55

Rachel Sarig (Weizmann Institute of Science, Rehovot, Israel)
p53 controls the destiny of differentiation and de-differentiation programs

Coffee break

16.40 - 17.20

Freddy Radtke (ISREC, Ecole Polytechnique Fédérale, Lausanne, Switzerland)
Notch signalling

17.20 - 18.00

Andreas Trumpp (DKFZ and HI-STEM, Heidelberg, Germany)

Dormancy in stem cells

18.00-19.00

Keynote Lecture
Hans Clevers (Hubrecht Laboratory, Utrecht, The Netherlands)
Wnt, Lgr5 stem cells and colon cancer

19.00

Closing remarks