Workshop

European Molecular Biology Organization

Programme

Session 1:  Transcriptional elongation and termination D. Eick, Munich Germany M. Hampsey, New Jersey USA R.  Landick, Madison USA J. Lis, Ithaca USA E. Nudler, New York USA D. Reinberg, New Jersey USA
Session 2: Interconnections between 3’ end processing, splicing and transcription D. Bentley, Denver USA S.  Buratowski, Boston USA H. Handa, Tokyo Japan A. Kornblihtt, Buenos Aires Argentina N. Proudfoot, Oxford UK S. Murphy, Oxford UK
Session 3:  RNA 3’ end processing: factors and mechanisms  J. Corden, Baltimore USA J. Greenblatt, Toronto Canada J. Manley, New York USA W. Marzluff, N. Carolina USA C. Moore, Boston USA L. Tong, New York USA R. Anderson Madison USA
Session 4:  3’ end formation and gene regulation/expression I T. Blumenthal, Boulder USA J. Richter, Worcester USA J. Steitz, New Haven USA F. Stutz, Geneva Switzerland D. Tollervey, Edinburgh UK C. Dean, Norwich UK
Session 5: 3’ end formation and gene regulation/expression II I. Bozzoni, Rome Italy T. Jensen, Aarhus Denmark D. Libri, Paris France J. Martinez, Vienna Austria M. Wickens, Madison USA F. Kleiman New York USA

Wednesday 16th Sept
pm	Arrivals
6.00-7.00 pm	Reception in Old Cloisters
7.00-8.30 pm	Dinner in Brasenose College Hall
8.30-late	College Bar
Thursday 17th Sept
7.30-8.30 a.m	Breakfast in Brasenose College Hall
9.00-12.30	Session 1: Chair: Steve Buratowski (Pharmacology Lecture Theatre)
	Transcription elongation and termination
9.00 - 9.30	John Lis
	Tracking transcription
9.30-10.00	Danny Reinberg
10.00-10.30	Shona Murphy
	Controlling expression of humansnRNA genes
10.30-11.00	Coffee break
11.00-11.30	Bob Landick
	Role of the RNA polymerase trigger loop in transcript elongation, cleavage, and pausing
11.30-12.00	Evgeny Nudler
	The Mechanism of Bacterial Transcription Termination
12.00-12.15	David Price  (short talk)
	Role of GDOWN1 in controlling elongation by RNA Polymerase
12.15-12.30	Joanna Kufel (short talk)
	Nrd1/Nab3-dependent mechanism for Pol I transcription termination on rDNA
1.00-2.00 pm	Lunch in Brasenose College Hall
	Thursday pm (Pharmacology Lecture Theatre)
2.30-6.15	Session 2: Chair: Jim Manley Coupling between transcription stages and RNA processing
2.30-3.00	Alberto Kornblihtt
	Chromatin, Pol II elongation and alternative splicing
3.00 - 3.30	David Bentley
	Coordination of pre-mRNA processing with RNA pol II CTD phosphorylation and transcription termination
3.30-4.00	Mike Hampsey
	Gene Loops and RNA Polymerase II Transcription
4.00-4.30	Tea Break
4.30-5.00	Nick Proudfoot
	Functions for polyA site dependent gene looping
5.00-5.30	Torben Jensen
	3’end formation stimulates transcription initiation
5.30-6.00	H. Handa
	Transcription elongation factors: mechanism of their action and their role in 3’ processing
6.00-6.15	Alexandra Moreira (short talk)
	The outcome of RNA polymerase II kinetics in Polo transcription termination
7.00-8.30 pm	Dinner in Brasenose College Hall
8.30-10.00	Poster Session I:  (Old Cloisters)
	Bar open till late

Friday 18th Sept
7.30-8.30 am	Breakfast in Brasenose College Hall
9.00-12.30	Session 3: Chair: Marv Wickens (Pharmacology Lecture Theatre)
	3’ ends and RNA turnover
9.00 - 9.30	Domenico Libri
	CUTs metabolism and transcription termination: stop making (anti)sense
9.30-10.00	Steve Buratowski
	Pre- and Post-transcriptional mechanisms for suppressing promiscuous   transcription
10.00-10.30	Jeff Corden
	Yeast RNA polymerase II non-poly(A) termination pathway: growth control and entry into stationary phase.
10.30-11.00	Coffee break
11.00-11.30	Francoise Stutz
	Antisense RNAs mediate transcriptional gene silencing in S. cerevisiae.
11.30-12.00	Joan Steitz
12.00-12.15	Joel Neilson (short talk)
	Deep sequencing analysis of mammalian immune cell activation suggests cell-specific programs of  3' UTR variation
12.15-12.30	Christine Mayr (short talk)
	Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells
1.00-2.00 pm	Lunch in Brasenose College Hall
2.30-5.45	Session 4: Chair: Joel Richter (Pharmacology Lecture Theatre)
	Factors and mechanisms
2.30-3.00	L. Tong
	Structural and functional studies of pre-mRNA 3’-end processing
3.00-3.30	Claire Moore
	Assembly of an export-competent mRNP is needed for efficient release of the 3’ end processing complex
3.30-3.45	Andrzej Dziembowski (short talk)
	Different RNA pathways towards the catalytic centres of the eukaryotic exosome complex
3.45-4.00	Stepanka Vanacova (short talk)
	Distinct Roles of TRAMP complexes in yeast RNA Metabolism
4.00-4.30	Tea Break
4.30-5.00	Bill Marzluff & Zbig Dominski
5.00-5.30	Marv Wickens
5.30-5.45	Chris Norbury (short talk)
	3′ uridylation promotes bulk mRNA decapping independently of deadenylation
7.00-8.30 pm	Dinner in Brasenose College Hall
8.30-10.00 p	Poster Session II:   Old Cloisters
	Bar open till late
Saturday 19th Sept
7.30-8.30 am	Breakfast in Brasenose College Hall
9.00-12.15	Session 5: Chair: Joan Steitz (Pharmacology Lecture Theatre)
	3’ ends and gene regulation I
9.00-9.30	Jack Greenblatt
9.30-10.00	Irene Bozzoni
	Coupling between transcription and processing promotes efficient expression of independently transcribed microRNA genes
10.00-10.15	Carol Lutz   (short talk)
	Cis-acting polyadenylation elements and their impact on alternative polyadenylation
10.15-10.30	Bin Tian (short talk)
	Alternative mRNA polyadenylation in development
10.30-11.00	Coffee break
11.00 - 11.30	Frida Kleiman
	The missing link: RNA 3’ end processing and DNA damage?
11.30-12.00	Tom Blumenthal
	Transcription and processing of polycistronic pre-mRNAs from C. elegans operons
12.00 -12.15	Andre Furger (short talk)
	Splicing and alternative poly(A) site use result in a novel Melanocortin-1- receptor that contains a C-terminal tubulin beta 3 extension
1.00-2.00 pm	Lunch in Brasenose College Hall
2.30-5.30	Session 6: Chair: Nick Proudfoot     (Pharmacology Lecture Theatre)
	3’ ends and gene regulation II

2.30-3.00	Dirk Eick
	Modification and function of the carboxy-terminal domain of RNA polymerase II (CTD)
3.00-3.30	Joel Richter
	Translational Control of Synaptic Plasticity
3.30 - 4.00	Richard Anderson
	A Phosphoinositide Regulated Poly(A) Polymerase Controls 3’-Processing of Select Messages
4.00-4.30	Tea Break
4.30-5.00	Caroline Dean
	Targeted 3’ processing of antisense transcripts triggers Arabidopsis FLC chromatin silencing
5.00-5.15	Gordon Simpson   (short talk)
	The Spen family protein, FPA, controls RNA 3’ end formation and this can explain its role in flowering and RNA silencing
5.15-5.45	Jim Manley
	Regulation of mammalian 3’ processing
6.30-7.00 pm	Reception in Old Cloisters
7.00-9.00 pm	Banquet in Brasenose College Hall
9.00-late	Bar and entertainment (Old Cloisters)
Sunday 20th September
8.00-9.00	Breakfast in Brasenose College Hall
am	Departures