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Thursday, 26th February |
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12.30-13.30 |
Lunch |
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| 15:55 - 16:00 |
Welcome and Opening Remarks
Kevin Docherty (Aberdeen, UK)
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16.00-18.00 |
Plenary 1: Islet Development (1)
Chair – Timo Otonkoski (Helsinki, Finland)
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Ken Zaret (Philadelphia,, USA)
Chromatin Features and Developmental Signals that Govern the Efficiency of Early Pancreatic Development |
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Chris Wright (Nashville, USA)
Lineage tracing studies of transcription factor interactions that regulate pancreatic progenitor behaviour |
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Ekhardt Lammert (Duesseldorf, Germany)
The vascular niche of pancreatic islets |
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Henrik Semb (Lund, Sweden)
Tubulogenesis and cell differentiation during pancreas development |
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18.30- 19.30 |
Dinner |
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19.30 -21.00 |
Keynote Lecture (45 min)
Chair: Kevin Docherty (Aberdeen, UK) |
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Sir Ian Wilmut (Edinburgh, UK)
New opportunities to study inherited metabolic disorders |
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Plenary 2: Islet Development (2) |
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Anne Grapin-Botton (Lusanne, Switzerland)
Endocrine differentiation from pancreas progenitors |
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Magenheim et al. (Jerusalem, Israel)
Blood vessels control differentiation and branching during pancreas morphogenesis |
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Friday 27th, February |
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9.00 – 12.30 |
Plenary 2: Embryonic Stem Cells
Chair: Alan Coleman (London, UK) |
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Ludovic Vallier (Cambridge, UK)
Differentiation of human pluripotent stem cells into pancreatic and hepatic progenitors using chemically defined culture conditions |
Ludin et al (Helsinki, Finland)
Maintenance of human pluripotent stem cell derived definitive endodermal progenitor cells in long-term culture |
Ed Baetge (San Diego, USA)
β cells from embryonic stem cells |
Mfopou et al. (Brussels, Belgium)
An original protocol for pancreatic cell differentiation generates liver-like cells from four human embryonic stem cell lines: a role for BMP and FGF pathways |
Mark Dunne (Manchester, UK)
Pax4 and Human ES Cells |
Lee (Menlo Park, USA)
Development of hESC-Based Therapies for Diabetes: Preclinical and
Clinical Perspectives |
| Debate (45 min) |
Ole Madsen (Gentofte, Denmark)
A road-map for stem cell use in diabetes therapy and prevention |
12.30 – 13.30 |
Lunch |
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13.30 – 15.00 |
Posters |
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15.00 – 17.00 |
Plenary 3: Imaging
Chair: Chris Rhodes (Chicago, USA) |
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Martin Gotthardt (Nijmegn, The Netherlands)
Current state-of-the-art in in vivo beta-cell imaging |
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Villiger et al. (Lusanne, Switzerland)
Optical coherence microscopy of endocrine islets |
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Ulf Ahlgren (Umea, Sweden)
Optical Projection Tomography (OPT) imaging of the developing and diabetic pancreas
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Plenary 4: Islet Development (3)
Chair – Mike German (San Francisco, USA) |
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Doris Stoffers (Philadelphia, USA)
Pdx1 partners and targets in beta cell differentiation |
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Vetere et al. (Boston, USA)
OVO Homolog-like 1 (OVOl1) Transcription Factor: a Novel Target of Neurogenin-3 in pancreas |
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Gerard Gradwohl (Strasbourg, France)
Transcriptional regulation of islet cell development |
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18:30 - 19:30 |
Dinner
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| 19:30 - 20:30 |
Plenary 5 : Islet Development (4)
Chair – Jorge Ferrer (Barcelona, Spain)
Mike German (San Francisco, USA)
Gene cascades controlling islet development
Isabelle Artner (Lund, Sweden)
Maf transcription factors and pancreas development
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Saturday 28th, February |
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9.00 – 12.30 |
Plenary 6: Regeneration (1)
Chair – Henrik Semb (Lund, Sweden)
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Susan Bonner-Weir (Boston, USA)
The role of pancreatic progenitors in pancreatic growth after birth |
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Minami et al. (Kobe, Japan)
A novel strategy for in vitro cell tracing reveals phenotypic reversibility of mouse pancreatic beta-cells |
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Harry Heimberg (Brussels, Belgium)
Beta cell progenitors in the adult pancreas |
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Solar et al. (Barcelona, Spain)
Analysis of the plasticity of HNF1b-expressing cells in the embryonic and adult pancreas |
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Rovira et al. (Baltimore, USA)
Characterization of high ALDH expressing cells in adult mouse and zebrafish |
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Timo Otonkoski (Helsinki, Finland)
Proliferation and differentiation of human β cells: Importance of extracellular matrix |
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Beucher et al. (Strasbourg, France)
Generation of insulin-expressing cells from intestinal cells |
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David Tosh (Bath, UK)
Conversion of liver cells to pancreatic β-cells |
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12.30 - 13.30 |
Lunch |
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13:30 – 17:00 |
Plenary 7: Regeneration (2)
Chair – Susan Bonner-Weir (Boston, USA) |
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Susumu Seino (Kobe, Japan)
Induction of insulin-secreting cells from pancreatic acinar cells in vitro and its mechanism |
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Bonal et al. (Geneva, Switzerland)
Pancreatic Inactivation of c-Myc Decreases Acinar Mass and Transdifferentiates Acinar Cells Into Adipocytes |
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Luc Bouwens (Brussels, Belgium)
Identifying progenitor cells for β cell regeneration in duct-ligated pancreas |
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Rooman (Brussels, Belgium)
Primary cultures of pancreatic acini acquire a precursor-like phenotype with senescent features |
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Yuval Dor (Jerusalem, Israel)
Glucose physiology and beta cell regeneration |
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Debate (45 min) |
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Chris Rhodes (Chicago, USA)
Therapeutic Consideration of β-Cell Regeneration |
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17:00 – 18.30 |
Poster Session |
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19.30 - late |
Dinner and Entertainment |
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Sunday 1st, March |
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09.00 – 12.00 |
Plenary 8: Development (4)
Chair – Ole Madsen (Gentofte, Denmark)
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Pedro Herrera (Geneva, Switzerland)
In vivo clonal analysis of islet progenitor cells |
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da Silva Xavier et al. (London, UK)
TCF7L2 regulates cell proliferation and differentiation in the developing pancreatic epithelia |
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van Arensbergen et al. (Barcelona, Spain)
Beta-cell differentiation involves de novo, lineage-specific H3K27me3-mediated repression. |
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Roland Stein (Nashville, USA)
Factors regulating activation by MafA and MafB in islets |
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Cano et al (Hebrok group) (San Francisco, USA)
Role of the tumor supressor gene VHL in beta cell formation and function |
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Jorge Ferrer (Barcelona, Spain)
Epigenetic regulation of pancreatic β -cells |
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Discussion (30 min) |
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Alan Colman (London, UK)
Summary and future directions |
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End of Meeting (Departure) |
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