Programme

Wednesday 17th

16:00 - 18:00

18:00 - 19:00

Plenaries 1 - Overview  on Cell Death

Pierre Golstein, Center of Immunology of Marseille-Luminy
“Cell death from basics to Dictyostelium”
Peter Krammer , German Cancer Research Center
“The Role of Cell Death in Tumor Immunity and Tolerance”

8:00-10:00

Symposium A: Modes of Cell Death

Chairman: Dr. Pierre Golstein

Speakers (3x 30'):

Peter Vandenabeele, University of Ghent
""Regulated versusaccidental necrosis: a comparative time-lapse analysis of cell death induced by TNF and hydrogen peroxide "

Adi Kimchi, Weizmann Institute.
“Systems level analysis of the programmed cell death network”

Beth Levine, SouthWestern Medical Center, Dallas
“New roles of autophagy  in cell death and cell growth control”

Speakers (3 x 10'):

Francis Chan, University of Massachussets
“A RNA interference screen identifies a kinase network that regulates TNF-induced programmed necrosis” 

Nele Vanlangenakker, University of Ghent
“RNAi screen reveals novel kinases involved in necrotic cell death”

  Herbert Virgin, Washington University
 “Role of autophagy genes ATG5 and ATG16L1 in immunity and inflammation”

Coffee Break

10:30-12:30

                            
Symposium B: Intrinsic molecular regulators of immune-mediated cell death
Chairman: Dr. Christoph Borner

Speakers (3 x 30'):

Thomas Kauffman, Walter and Eliza Hall Institute/University of Bern
"The role of pro-apoptotic BH3-only proteins in death receptor-induced apoptosis"

Georg Häcker, Technical University, Munich
“The mitochondrial apoptotic pathway in the host defence against viral infection”

Eileen White, The Cancer Institute of New Jersey
“Role of apoptosis and autophagy in cancer therapy”

Speakers (3 x 10'):

José A. Carrodeaguas, University  of Zaragoza
“Two apoptotic domains of PSAP/Mtch1 induce apoptosis in a Bax/Bak-independent manner when exposed on the surface of mitochondria”

Ellen Wirawan, University of Ghent
“Caspase dependent cleavage of beclin ehances apoptotic cell death”

Christoph Borner, University of Freiburg
“Are cathepsins really initiators of apoptosis in immune cells?”

Lunch

15:30-17:30       

Symposium C: Molecular basis and biological significance of granzyme-induced cell death

Chairman: Dr. Markus Simon

Speakers (4x20'):

Denis Martinvalet,  Harvard University
“Granzyme A activates a caspases-independent mitochondrial cell death pathway by targeting complex I”

Christopher J. Froelich, Northwestern University
"Granzyme A induces a pro-inflammatory cytokine response without cytotoxicity"

Julián Pardo, University of Zaragoza
"Similar and diverse biological activities of mouse granzymes A and B: lessons from ex vivo CTL"

Felipe Andrade, John Hopkins University
“Granzymes and their non-apoptotic antiviral activities”

Speakers (3 x 10'):

Desiree Anthony, Peter MacCallum Cancer Center
“Granzyme M as a modulator of the inflammatory response”

Praxedis Martin, Max-Planck Institute for Immunobiology
“Granzyme B of cytotoxic T lymphocytes is critical for caspase-3/-7 generated fragmentation of gelsolin”

Seamus Martin,Dublin Trinity College
“Identification of novel granzyme B and M substrates”

Coffee Break

18:00 - 19:00

19.00 – 20.00

Poster session I

Friday 19th

8:00-10:00    

Symposium D: Cell death in the development and control of immunity
Chairman: Dr. Peter H. Krammer

Speakers (3 x 30'):

Karsten Gülow, German CancerResearch Center
“Oxidative signaling and regulation of Apoptosis in T cells”

Henning Walczak, Imperial College, London
"TRAIL-induced apoptosis:  primary tumour versus metastasis"

Rüdiger Arnold, German CancerResearch Center
“The NF-kB regulator HPK1 as a molecular switch between life and
death in lymphocytes”

Speakers (3 x 10'):

Heather Marshall, University of Massachussets
“Opposing responses of bystander CD8 T cells activated by cognate antigen during acute viral infections: enhanced activation yet diminished proliferation” 

Alberto Anel, University of Zaragoza
“Cell cycle regulation by FasL and Apo2L/TRAIL in human T cell blasts. Implications for autoimmune lymphoproliferative syndromes (ALPS)”

Iván Bernardo, 12 de Octubre Hospital, Madrid
“Role of Activation-Induced Cell-Death (AICD) of human T-lymphocytes in patients with defective cytotoxic T-cell function”

Coffee Break

10:30-12:30        

Symposium E: Cell death as a consequence of the immune response
Chairman: Dr. Julián Pardo

Speakers (4x20'):

Matthew F. Mescher, Center for Immunology, Minneapolis
"Programming naive CD8 T cells for development of effector functions and memory".

Hans-Gustaf Ljunggren, Karolinska Institute
  “Clinical manifestations of defects in NK cell-mediated cytotoxicity”

Arturo Zychlinsky , Max-Planck Institute for Infection Biology
“NETs: novel cell death leads to innate immune response”

Olaf Utermoehlen, Koln Institut  for Medical Microbiology
  “Acid sphingomyelinase is a critical regulator of cytotoxic granule secretion by primary T lymphocytes”

Speakers (3x10'):

Gideon Berke, Weizmann Institute
“As an immune response develops in vivo the killing phenotype of the CTL population switches from perforin- to Fas ligand-based killing” 

Tiziana Daniele, University of Cambridge
“The role of Rab7 in the movement of the secretory lysosomes”

Noa Martin-Cofreces, Hospital de la Princesa, Madrid
“MTOC translocation modulates IS formation and controls sustained T cell activation”

Lunch

15:30 -17:30

Symposium F: Tumour immunity

Chairman: Dr. Joe Trapani  

Speakers (3 x 30'):

Cornelis J. M. Melief, Leiden University
“Therapeutic vaccination against established disease caused by high risk human papilloma virus”

Jean Paul Medema , Academic Medical Center, Amsterdam
“Apoptosis regulation in solid tumors”.

Thomas Sayers, National Cancer Institute Frederick
“Bortezomib sensitizes renal cancer cells to TRAIL-mediated apoptosis in vitro and in vivo”

Speakers (3x10'):

Ignacio Melero, Applied Medicine Research Center, Pamplona
“The multifaceted pharmacological mechanism of action of CD137 (4-1BB) targeted immunotherapies”

Phillip Krebs, The Scripps Research Institute
“A novel pathway linking innate to adaptive immunity through NK cells”                                               

Martín Villalba, Molecular Genetics Institute, Montpellier
“Impaired anti-leukemic immune response in PKC-θ-deficient mice”

Coffee Break

18:00-19:00  

19:00-20:00

Poster session II

Saturday  20th

9:00-11:00

Symposium G: Cell death relevance during the immune response to pathogens
Chairman: Dr. Arno Müllbacher and Chris Bleackley

Speakers (3 x 30'):

Raymond Welsh, University of Masachussets
“T cell attrition and loss of memory during viral infection”

Matthias Regner, John Curtin School of Medical Research
"Role of granzyme B in the cytotoxic T cell attack against the natural mouse pathogen, ectromelia virus”

Chris Bleackley , University of Alberta
" Is it possible to leave granzymes?"

Speakers (3 x 10'):

Adriana Aporta, University of Zaragoza
“Cell death induced on macrophages by Mycobacterium tuberculosis or attenuated strains”

Daniel Limonta, Pedro Kouri Institute of Tropical Medicine
“Apoptosis in white blood cells and tissues from dengue hemorrhagic fever fatalities”

Gennadiy Zelinskyy , Essen Clinical University
“Different cytolytic pathways of CD8 T cell mediated control of retroviral infection and counter-regulation by regulatory T cells”

Coffee Break

11:30-13:30

Symposium H:  Immune response misdirection/malfunction
Chairman: Dr. Alberto Anel

Speakers (3 x 30'):

Alain Fischer, Necker Hospital, Paris
"Genetic defects of lymphocyte cell death"

Klaus Michael Debatin, University of Ulm
"Apoptosis control in cancer and lymphoid homeostasis"

Ilia Voskoboinik , Peter MacCallum Cancer Center
“Sub-total loss of perforin function and susceptibility to cancer in humans”

Selected abstract from “Perforin mechanism of action” section
(10’ talk)

Katherine Baran, Peter MacCallum Cancer Center
“A molecular basis for perforin oligomerization and transmembrane pore assembly”

Speakers (2x10’)

Ilaria Seren-Bernardone, University of Eastern Piedmont
“Variations of the perforin gene in patients with autoimmune diseases”

Kiran Yanamandra, Umea University
“Immune reactivity towards insulin, insulin amyloids and S100B in blood sera of Parkinson’s disease patients”

Symposium I: Summing up and future directions  (x 30')