Skip to: site menu | section menu | main content

|
|
|
|
|
10-12 Sept | 2007| Krakow | Poland

Update: click HERE for Final progamme PLUS full workshop pdf

About the Workshop

         

 


The concept of epithelial-mesenchymal (EMT) transition describes a fast and sometimes reversible modulation of cell phenotype occurring during development at key stages of embryogenesis

Download Poster (pdf - click on image )

Normal mammary epithelial cells undergoing EMT in response to transforming growth factor β. Polarized
epithelial cells and mesenchymal derivative cells are stained for their actin cytoskeleton, which
undergoes re-organization
(Courtesy of A. Moustakas, Ludwig Institute for Cancer Research, Uppsala)


Cells expressing epithelial characteristics loosen desmosomes and adherens junctions and typically become isolated and motile.  They change their polarity and modulate their cytoskeleton, involving a switch from cytokeratins to vimentin intermediate filaments. Based on the involvement of common molecular pathways, the concept has been extended to partial EMT occurring during wound healing, tissue morphogenesis or pathologically during carcinoma progression and fibrotic processes. 

a Colon cancer cells undergoing EMT in response to transforming growth factor β. Polarized epithelial cells are stained with the adherens junction marker E-cadherin. Mesenchymal cells are stained with the intermediate filament marker vimentin.
(Courtesy of C. Hill, Cancer Research UK, London.)

   

This workshop is intended to connect researchers from various disciplines working on distinct aspects of EMT models in various animal models and human pathological situations.

The workshop will provide good opportunities for sharing, defining and classifying the growing number of EMT occurrences based on inducing and effector pathways.

This meeting is the third international symposium organized by TEMTIA (The EMT international organization after Port-Douglas (2003) and Vancouver (2005).

The meeting is co-organized with EpiPlastCarcinoma, a European network dedicated to the study of carcinoma cell plasticity during tumor invasion and metastasis.

 

 

 

 

 

 

 


 

 

 


 

 

Back to top