Drug Action & Chemical Biology in the Post-Genomic Era, 23-26 August 2007, Vienna, Austria

Programme (Download programme: word.doc ) Thurs 23rd \| Friday 24th \| Saturday 25th \| Sunday 26th

Thursday, August 23
18:00 - 22:00	Registration, beer and würstel
	*Session 1* ABSTRACT PRESENTATIONS *(Chair: Ulrike Eggert)*
19:30 - 19:50	Peter LENART, Research Institute of Molecular Pathology *The small-molecule inhibitor BI 2536 reveals roles of Polo-like kinase 1 in mitotic entry and maintenance of stable attachment of kinetochore microtubules*
19:50 - 20:10	Adam CASTORENO, Dana-Farber Cancer Institute/ Harvard Medical School *Combining chemical genetics and RNAi to identify small molecules that target the Rho pathway*
20:10 - 20:30	Ruth BIRNER-GRUENBERGER, Medical University of Graz *Activity-based proteome mapping of lipases and esterases in murine liver*
20:30 - 20:50	Fabio FALSONE, University of Graz *Proteome-wide consequences of Hsp90 inhibition*
20:50 - 21:10	Magdalena ZAJAC, Spanish National Cancer Research Centre (CNIO) *Mitotic catastrophe cell death induced by HSP90 inhibitor*
Friday August 24th	TOP

8:30 - 8:45	Welcome (Ulrike Eggert, Giulio Superti-Furga)
	*Session 2* *CELL CYCLE, CELL DIVISION, CANCER* *(Chair: Sebastian Nijman*)
8:45 - 9:20	Thomas MAYER, MPI Munich *Small molecules: versatile tools to study mitosis in higher eukaryotes*
9:20 - 9:55	Giulio SUPERTI-FURGA, CeMM *Molecular machines, molecular networks and the mechanism of action of drugs*
9:55 - 10:30	Tarun KAPOOR, Rockefeller University *Chemical biology of cell division*
10:30 - 11:00	Coffee Break
11:00 - 11:35	Ulrike EGGERT, Dana-Farber Cancer Institute/ Harvard Medical School *Small molecule probes of cytokinesis*
11:35 - 12:10	Robert BROWN, Imperial College London *Rational anticancer drug development: smart drugs or smarter clinical trials?*
12:10 - 12:45	Sandrine IMBEAUD, CNRS France *Predicting response to chemotherapy through transcriptome analysis, functional annotation and systems modelling*
12:45 - 15:30	*Lunch and Poster Session*
	*Session 3* EXPLOITING PROPERTIES OF ENZYMES (Chair: Giulio Superti-Furga)
15:30 - 16:05	Kai JOHNSSON, Ecole Polytechique Federal de Lausanne *Observing and manipulating proteins in living cells*
16:05 - 16:40	Gerard DREWES, Cellzome Quantitative proteomics reveals novel mechanisms of action for clinical kinase drugs
16:40 - 17:15	Nathanael GRAY, Dana-Farber Cancer Institute/ Harvard Medical School *Chemical approaches for targeting the kinome*
17:15 - 17:50	Stephen FESIK, Abbott *Bcl-2 family inhibitors for the treatment of cancer*
Evening	*Dinner at Heurigen Welser*

Saturday, August 25th	TOP

	*Session 4* DRUGS AND PATHWAYS (Chair: Robert Kralovics)
8:45 - 9:20	Thijn BRUMMELKAMP, Whitehead Institute / MIT *RNAi library screens identify cancer genes and study drug action*
9:20 - 9:55	Julian DOWNWARD, Cancer Research UK , Lond on Functional genomic analysis of Ras oncogene signaling and chemotherapeutic drug action
9:55 - 10:30	Jing HUANG, UCLA *Drugs and biological networks*
10:30 - 11:00	Coffee Break
	*Session 5* NEW TOOLS, NEW PERSPECTIVES (Chair: Sylvia Knapp)
11:00 - 11:35	Laura KIESSLING, University of Wisconsin- Madison *Chemical probes of mycobacterial cell wall biosynthesis*
11:35 - 12:10	Matt BOGYO, Stanford University Applications of activity based probes for in vivo pharmacodynamic and drug selectivity studies
12:10 - 12:45	Ron RAINES, University of Wisconsin- Madison *Ribonucleases as cancer chemotherapeutics*
12:45 - 13:20	Benjamin CRAVATT, The Scripps Research Institute *Mapping biochemical pathways in human disease by integrated proteomics and metabolomics*
13:20 - 14:45	*Lunch*
	*Session 6* DRUGS AND MODEL ORGANISMS (Chair: Nathanael Gray)
14:45 - 15:20	Mike TYERS, MSHRI Toronto *Title coming soon*
15:20 - 15:55	Peter ROY, University of Toronto *Exploring the utility of C. elegans to understand drugs and the* *mechanisms of their action*
15:55 - 16:30	Michael HOCH, Bonn University *Merging Drosophila genetics with chemical biology in the analysis of cell growth and signalling*
16:30 - 16:50	Coffee Break
16:50 - 17:25	Fabio PIANO, NYU *Title coming soon*
17:25 - 18:00	Randall PETERSON, Massachusetts General Hospital / Harvard Medical School *Exploring the development-disease connection by zebrafish chemical biology*
20:00	*Gala Dinner at the Natural History Museum*

Saturday August 26th	TOP
	*Session 7* SYSTEMS BIOLOGY AND IN SILICO APPROACHES (Chair: Christoph Binder)
9:35 - 10:10	Jonathan MASON, Lundbeck Research, DK *Describing and differentiating drugs by descriptors more relevant than structure: Biological fingerprinting & in silico approach*
10:10 - 10:45	Hans Peter FISCHER, Genedata, Geneva Investigating drug response by analyzing expression patterns: Closing the gap between efficacy and safety assessment
10:45 - 11:15	*Coffee Break*
11:15 - 11:50	Klaus WEINBERGER, BIOCRATES Life Sciences The renaissance of biochemistry: Targeted metabolomics and its contributions to drug safety and efficacy
11:50 - 12:25	Robert McBURNEY, BG Medicine *A systems biology approach to drug efficacy and safety*
12:25 – 14:00	Lunch

	*Session 8* NATURAL PRODUCTS AND CLINICAL COMPOUNDS (Chair: Ulrike Eggert)
14:00 - 14:35	Markus MÜLLER, Medical University of Vienna *Clinical pharmacogenetics: Visions and challenges*
14:35 - 15:10	Jon CLARDY, Harvard Medical School *Chemical ecology in the post-genomic era*
15:10 - 15:45	Jan-Michael PETERS, IMP Vienna *Anti-mitotic compounds as tools for basic research and cancer therapy*
15:45 - 16:00	Closing Remarks (Ulrike Eggert, Giulio Superti-Furga)
	TOP

Co-Sponsors