Practical Course

European Molecular Biology Organization


Genomes, Cells & Systems

6 - 13 August, 2011 | Reykjavík | Iceland

About the Practical Course

Image courtesy of: Gudmundur Ingolfsson

Recent improvement in technologies have allowed, for the first time, the generation of huge genomics, transcriptomics, metabolomics, and epigenomics data sets, even in large mammalian genomes, at a throughput that was unthinkable until a few years ago. Our course will illustrate recent advances in technology and cover various flavors of analyzing the data with computational biology related approaches.


In this regard, we will connect sequencing data and data on biomolecular structures (e.g. protein structures) with the analysis of complex systems. For example, advances in DNA sequencing have paved the way for the sequencing, with state-of-the-art technology, of thousands of human genomes to identify population genetic variants and associate these variants with diseases such as cancer.


Furthermore, at the level of more complex systems, advances in systems biology were recently realized by the metabolic reconstruction approach, i.e. the reconstruction of metabolic models at the level of cells up to the level of an entire organism (mice and humans). In addition, the sequencing of entire habitats of microbes colonizing the human gut has enabled new views on the role of gut bacteria on human metabolism and disease.


The expertise of the local organizers in computational systems biology will constitute an opportunity for the students to learn how to treat these different types of information, available at different scales, separately as well as in an integrated fashion.


For instance, the interpretation of metabolic reconstruction data inevitably depends on genome sequencing and genetic variation data, and connecting between these different types of information affords a view of the ‘big picture’, that is, how DNA sequence variation influences the phenotype and may lead to human diseases.


We look forward to welcoming you to Reykjavík!
The Organisers






European Molecular Biology Organization | Meyerhofstrasse 1 | 69117 Heidelberg | Germany