Practical Course

European Molecular Biology Organization

Structural proteomic projects have been initiated world-wide with the aim of carrying out high throughput structure determination on a genome-wide scale.

Crucial to this effort has been the development of HTP technologies for protein production (cloning, expression purification), protein crystallization and improved methods for structure solution by X-ray crystallography.

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			The aim of this course will be to review the state-of-the-art in HTP structural biology with an emphasis on methods to study complex and ‘difficult’ targets.

	Practical training will be provided in: - HTP protocols for cloning - protein expression screening (using both E. coli and eukaryotic systems) - protein purification and crystallization.   Participants will be able to apply the protein production and crystallization methods to their own protein target(s) with the option of entering their target(s) into the process  at various stages.   We look forward to seeing you in Oxford! The Organizing Committee
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