About the Practical Course

This course will allow the students to learn and practice recently developed methods allowing the combination of Electron Microscopy and X-ray crystallography, in particular:

• Fitting of X-Ray models into EM reconstructions, including flexible fitting with normal modes analysis.

• Use of an EM reconstruction as an initial phasing model to determine a crystal structure at higher resolution. 
  

Most laboratories involved in the structural determination of large biological objects (viruses, protein complexes) should be interested by the methods exposed in our course.

In the morning there will be 2 or 3 classes

In the afternoon there will be practical applications on the computer (in our computer room-
it is not necessary to bring your own). Please see the programme for further details.