Conference Series

European Molecular Biology Organization

 

CANCER PROTEOMICS

Systems Biology, Developmental
Models & Data Integration

 

 

 

 

 

 



20 - 23 June| 2011|The Burlington Hotel | Dublin | Ireland

Programme

 

Download Programme: (word.doc)  
   

Monday 20th June 2011

 

Educational Session - Integrated analysis of data analysis for cancer systems biology

 

Chairperson: Ben Collins

 

08.30-09.00

Registration (educational session)

 

09.00-09.40

Matthias Mann – Max Planck Institute for Biochemistry, Martinsried, Germany

 

“MaxQuant and Perseus for the bioinformatic analysis of quantitative proteome data”

09.40-10.20

Rolf Apweiler – European Bioinformatics Institute, Hinxton, UK

 

"Using proteomic data resources to identity novel cancer targets"

10.20-10.40

Coffee

 

10.40-11.20

Aedin Culhane – Dana-Farber Cancer Institute, Boston, USA

 

 

“Using curated gene information in statistical meta-analysis of genomics data”

 

11.20-12.00

Fredrik Ponten – Uppsala University, Sweden

 

  “Using the Human Protein Atlas portal as a tool for finding protein expression patterns”  

12.00-13.00

Lunch (educational session attendees only)

 

12.30-13.15

Registration (main program)

 

Session 1 - Quantitative proteomics in cancer systems biology I – cells and tissues

 

Chairperson: William Gallagher

 

13.20-13.30

Welcome and opening remarks (William Gallagher)

 

13.30-14.20

Opening Keynote Lecture: Matthias Mann – Max Planck Institute for Biochemistry, Martinsried, Germany

 

 

"Super-SILAC technology to accurately quantify the cancer proteome"

 

14.20-14.55

Fredrik Ponten – Uppsala University, Sweden

 

 

"A Human Protein Atlas for profiling normal and cancer cells and tissues"

 

14.55-15.20

Proffered Talk 1: Laoighse Mulrane – UCD Conway Institute, Dublin, Ireland

 

 

“MiR-187 is a marker of poor prognosis in estrogen receptor-positive breast cancer”

 

15.20-15.50

Coffee/Trade exhibit

 

15.50-16.25

Laura Beretta – Fred Hutchinson Cancer Research Center, Seattle, USA

 

 

"Hepatocellular carcinoma proteomics"

 

16.25-17.00

Connie Jimenez – VUmc-Cancer Center Amsterdam, The Netherlands

 

 

"Label-free mass spectrometry-based proteomics for biomarker discovery in murine and human cancer"

 

17.00-17.25

Proffered Talk 2: Sara Zanivan – Beatson Institute for Cancer Research, Glasgow, United Kingdom

 

 

“In vivo quantitative proteomics and phosphoproteomics of skin cancer development”

 

17.25-17.50

Proffered Talk 3: Francois-Michel Boisvert – University of Dundee, United Kingdom

 

 

“A quantitative spatial proteomics analysis of proteome turnover in human cancer cells”

 

17.50

Welcome Reception and Trade Exhibit

 

   

Tuesday 21st June 2011

 

Session 2 - Cancer stem cells and developmental model systems

 

Chairperson: Serhiy Souchelnytskyi

 

09.00-09.35

Tony Whetton – University of Manchester

 

 

“Proteomic studies on normal and leukaemic stem cells reveal novel regulatory pathways in drug responses”

 

09.35-10.10

Xiaoyan Jiang – University of British Columbia, Vancouver, Canada

 

 

“A novel AHI-1-BCR-ABL-JAK2 interaction complex mediates cellular resistance to tyrosine kinase inhibitors in chronic myeloid leukemia stem cells”

 

10.10-10.35

Proffered Talk 4: Leonie Norris – University of Leicester, United Kingdom

 

 

“A strategy for label-free quantification of protein biomarkers in cancer stem-like cells”

 

10.35-11.05

Coffee/Trade exhibit

 

11:05 - 11:40

Eileen Furlong – European Molecular Biology Laboratory, Heidelberg, Germany
“Transcriptional networks during development - Deciphering the code”

 

11.40 - 12.05

Proffered Talk 5: Veronica Miguela – Instituto de Neurociencias, Alicante, Spain
“Looking for new partners in crime for the tumorigenic activity of Pipsqueak”

 

12.05-12.50

Lunch/Trade exhibit

 

Poster Session 1

 

 

12.50 - 13.50

Authors of even numbered posters in attendance

 

Session 3 – Proffered talk session

 

Chairperson: William Gallagher

 

13:50 - 14:15

Proffered Talk 6: Safia Thaminy – Institute of Molecular Systems Biology, Zurich, Switzerland

 

 

“Integrated proteomic and siRNA screen analysis to study the migratory phenotype of breast cancer cell lines”

(Abstract selected for emerging investigator award)

 

14.15-14:40

Proffered Talk 7: Tamar Geiger – Max Planck Institute of Biochemistry, Martinsried, Germany

 

 

“A proteomic portrait of human breast cancer progression”

 

14.40 - 15.05

Proffered Talk 8: Bodo Lange – Max-Planck Institut für molekulare Genetik, Berlin, Germany

 

 

“Functional characterisation of a centrosome protein interaction network relating to centrosome biogenesis and aberration in cancer cells”

 

15.05 - 15.30

Proffered Talk 9: Adam Byron – University of Manchester, United Kinddom

 

 

“Proteomic analysis of integrin adhesion signalling in cancer cells”

 

15.30 - 15.55

Proffered Talk 10: Aaron Robitaille - Biozentrum, University of Basel, Switzerland

 

 

“Quantitative analysis of the mTOR signaling network”

(Abstract selected for emerging investigator award)

 

15:55 - 16:25

Coffee/Trade exhibit

 

Session 4 - Quantitative proteomics in cancer systems biology II – biofluids

 

Chairperson: Connie Jimenez

 

16.25-17.200

Stephen Pennington – University College Dublin, Ireland
“Cancer Proteomics: Promise or Progress?”

 

1700-17:35

Michael Gillette – Broad Institute of MIT and Harvard, Cambridge, USA

 

 

“Progress toward a biomarker discovery-to-development pipeline in clinical proteomics”

 

17.35 - 18.10

Ruth Hüttenhain Institute for Molecular Systems Biology, ETH Zurich, Switzerland

 

 

“Cancer genetics-guided discovery of protein biomarkers and their SRM-based verification in plasma”

 

18.10 - 18.35

Proffered Talk 11: Yue Fan – UCD Conway Institute, Dublin, Ireland

 

 

“Label-free LC-MS/MS and MRM development for discovery and verification of biomarkers for prostate cancer”

 

   

Wednesday 22nd June 2011

 

09.00-09:45

Address by Minister of State

 

Session 5 - Data integration I – Cellular signalling networks

 

Chairperson: Walter Kolch

 

09.45 - 10.20

Emmanuel Barillot – Institut Curie, Paris, France

 

 

"Modeling biological networks involved in tumor progression"

 

10.20 - 10.55

Rune Linding – Technical University of Denmark, Lyngby, Denmark

 

 

"Cancer network medicine and cellular information processing"

 

10.55 - 11.25

Coffee/Trade exhibit

 

11.25 - 12.00

Ulrike Eggert– Dana Farber Cancer Institute, Boston, USA

 

 

"A combined chemical genetic/RNAi approach to study cell signalling"

 

12.00 - 12.35

Christie Sers– Charité Universitätsmedizin Berlin, Germany 

 

 

"Systems biology in predictive medicine"

 

12.35 - 13.25

Lunch/Trade exhibit

 

Poster Session 2

 

 

13.25 - 14.25

Authors of odd numbered posters in attendance

 

Session 6 - Protein complexes and protein-protein interaction networks

 

Chairperson: Tony Ng

 

14.25 - 15.00

Andrew Emili University of Toronto, Toronto, Canada

 

 

"Interaction networks and chromatin-related protein complexes in cancer"

 

15.00 - 15.35

Walter Kolch– Systems Biology Ireland, Dublin, Ireland

 

 

“Signalling networks and systems biology”

 

15.35 - 16.10

Michael Cusick – Dana-Farber Cancer Institute, Boston, USA

 

  "Interactome networks & human disease"  

16.10 - 16.40

Coffee/Trade exhibit

 

16.40 - 17.15

Igor Stagljar University of Toronto, Canada

 

 

"Protein interaction networks regulating cell signalling in cancer"

 

17.15 - 17.40

Proferred Talk 12: Anthony Coolen –King's College London, United Kingdom

 

 

“Non-equilibrium statistical mechanics of signalling in large protein interaction networks”

 

evening

 Conference Dinner and Entertainment

 

   

Thursday 23rd June 2011

 

Session 7 - Data integration II – global views of cancer processes

 

Chairperson: Rolf Apweiler

 

09.00-09.35

Søren Brunak– Technical University of Denmark, Kongens Lyngby, Denmark

 

 

“Integrating healthcare sector data with molecular data in cancer”

 

09.35-10.10

Anne-Lise Børresen-Dale – The Norwegian Radium Hospital, Oslo, Norway

 

 

"Integrated genomics of breast cancer"

 

10.10-10.40

Coffee/Trade exhibit

 

10.40-11.15

Aedin Culhane Dana-Farber Cancer Institute, Boston, USA

 

 

“Computational Discovery of the Hallmarks of Cancer through Meta Gene Set Analysis”

 

11.15-11.50

Lodewyk Wessels – Netherlands Cancer Institute, Amsterdam, The Netherlands

 

 

“Oncogenic pathway identification through itegration of diverse, same sample data sources”

 

11.50-12.50

Lunch/Trade exhibit

 

Session 8 - Connecting systems approaches to commercial and clinical use

 

Chairperson: Stephen Pennington

 

12.50-13.25

Serhiy Souchelnytskyi – Karolinska Biomics Center, Stockholm, Sweden

 

 

"Personalized medicine and cancer proteomics"

 

13.25-14.00

Tony Ng - King's College London, UK
“Use of nanoscopic cancer tissue imaging, gene bioinformatics and mathematical modelling to predict the metastatic outcome of breast cancer sufferers“

 

14.00-14.25

Proferred Talk 13: Steven Kornblau – U. Texas M.D. Anderson Cancer Center, Houston, USA

 

 

“Proteomic analysis of the signaling pathways underlying acute myeloid leukemia”

 

14.25-14.55

Coffee/Trade exhibit

 

14.55-15.30

William Gallagher – University College Dublin, Dublin, Ireland
“Bridging the translational divide: converting omic datasets into clinical relevant assays”

 

15.30-16.20

Closing Keynote Lecture: Dario Neri – Institute of Pharmaceutical Sciences ETH Zurich, Switzerland

 

 

"Vascular tumor targeting: from target discovery to clinical trials"

 

16.20-16.25

Closing Remarks (William Gallagher)

 



 

European Molecular Biology Organization | Meyerhofstrasse 1 | 69117 Heidelberg | Germany