Conference Series

European Molecular Biology Organization



Systems Biology, Developmental
Models & Data Integration







20 - 23 June| 2011|The Burlington Hotel | Dublin | Ireland



Download Programme: (word.doc)  

Monday 20th June 2011


Educational Session - Integrated analysis of data analysis for cancer systems biology


Chairperson: Ben Collins



Registration (educational session)



Matthias Mann – Max Planck Institute for Biochemistry, Martinsried, Germany


“MaxQuant and Perseus for the bioinformatic analysis of quantitative proteome data”


Rolf Apweiler – European Bioinformatics Institute, Hinxton, UK


"Using proteomic data resources to identity novel cancer targets"





Aedin Culhane – Dana-Farber Cancer Institute, Boston, USA



“Using curated gene information in statistical meta-analysis of genomics data”



Fredrik Ponten – Uppsala University, Sweden


  “Using the Human Protein Atlas portal as a tool for finding protein expression patterns”  


Lunch (educational session attendees only)



Registration (main program)


Session 1 - Quantitative proteomics in cancer systems biology I – cells and tissues


Chairperson: William Gallagher



Welcome and opening remarks (William Gallagher)



Opening Keynote Lecture: Matthias Mann – Max Planck Institute for Biochemistry, Martinsried, Germany



"Super-SILAC technology to accurately quantify the cancer proteome"



Fredrik Ponten – Uppsala University, Sweden



"A Human Protein Atlas for profiling normal and cancer cells and tissues"



Proffered Talk 1: Laoighse Mulrane – UCD Conway Institute, Dublin, Ireland



“MiR-187 is a marker of poor prognosis in estrogen receptor-positive breast cancer”



Coffee/Trade exhibit



Laura Beretta – Fred Hutchinson Cancer Research Center, Seattle, USA



"Hepatocellular carcinoma proteomics"



Connie Jimenez – VUmc-Cancer Center Amsterdam, The Netherlands



"Label-free mass spectrometry-based proteomics for biomarker discovery in murine and human cancer"



Proffered Talk 2: Sara Zanivan – Beatson Institute for Cancer Research, Glasgow, United Kingdom



“In vivo quantitative proteomics and phosphoproteomics of skin cancer development”



Proffered Talk 3: Francois-Michel Boisvert – University of Dundee, United Kingdom



“A quantitative spatial proteomics analysis of proteome turnover in human cancer cells”



Welcome Reception and Trade Exhibit



Tuesday 21st June 2011


Session 2 - Cancer stem cells and developmental model systems


Chairperson: Serhiy Souchelnytskyi



Tony Whetton – University of Manchester



“Proteomic studies on normal and leukaemic stem cells reveal novel regulatory pathways in drug responses”



Xiaoyan Jiang – University of British Columbia, Vancouver, Canada



“A novel AHI-1-BCR-ABL-JAK2 interaction complex mediates cellular resistance to tyrosine kinase inhibitors in chronic myeloid leukemia stem cells”



Proffered Talk 4: Leonie Norris – University of Leicester, United Kingdom



“A strategy for label-free quantification of protein biomarkers in cancer stem-like cells”



Coffee/Trade exhibit


11:05 - 11:40

Eileen Furlong – European Molecular Biology Laboratory, Heidelberg, Germany
“Transcriptional networks during development - Deciphering the code”


11.40 - 12.05

Proffered Talk 5: Veronica Miguela – Instituto de Neurociencias, Alicante, Spain
“Looking for new partners in crime for the tumorigenic activity of Pipsqueak”



Lunch/Trade exhibit


Poster Session 1



12.50 - 13.50

Authors of even numbered posters in attendance


Session 3 – Proffered talk session


Chairperson: William Gallagher


13:50 - 14:15

Proffered Talk 6: Safia Thaminy – Institute of Molecular Systems Biology, Zurich, Switzerland



“Integrated proteomic and siRNA screen analysis to study the migratory phenotype of breast cancer cell lines”

(Abstract selected for emerging investigator award)



Proffered Talk 7: Tamar Geiger – Max Planck Institute of Biochemistry, Martinsried, Germany



“A proteomic portrait of human breast cancer progression”


14.40 - 15.05

Proffered Talk 8: Bodo Lange – Max-Planck Institut für molekulare Genetik, Berlin, Germany



“Functional characterisation of a centrosome protein interaction network relating to centrosome biogenesis and aberration in cancer cells”


15.05 - 15.30

Proffered Talk 9: Adam Byron – University of Manchester, United Kinddom



“Proteomic analysis of integrin adhesion signalling in cancer cells”


15.30 - 15.55

Proffered Talk 10: Aaron Robitaille - Biozentrum, University of Basel, Switzerland



“Quantitative analysis of the mTOR signaling network”

(Abstract selected for emerging investigator award)


15:55 - 16:25

Coffee/Trade exhibit


Session 4 - Quantitative proteomics in cancer systems biology II – biofluids


Chairperson: Connie Jimenez



Stephen Pennington – University College Dublin, Ireland
“Cancer Proteomics: Promise or Progress?”



Michael Gillette – Broad Institute of MIT and Harvard, Cambridge, USA



“Progress toward a biomarker discovery-to-development pipeline in clinical proteomics”


17.35 - 18.10

Ruth Hüttenhain Institute for Molecular Systems Biology, ETH Zurich, Switzerland



“Cancer genetics-guided discovery of protein biomarkers and their SRM-based verification in plasma”


18.10 - 18.35

Proffered Talk 11: Yue Fan – UCD Conway Institute, Dublin, Ireland



“Label-free LC-MS/MS and MRM development for discovery and verification of biomarkers for prostate cancer”



Wednesday 22nd June 2011



Address by Minister of State


Session 5 - Data integration I – Cellular signalling networks


Chairperson: Walter Kolch


09.45 - 10.20

Emmanuel Barillot – Institut Curie, Paris, France



"Modeling biological networks involved in tumor progression"


10.20 - 10.55

Rune Linding – Technical University of Denmark, Lyngby, Denmark



"Cancer network medicine and cellular information processing"


10.55 - 11.25

Coffee/Trade exhibit


11.25 - 12.00

Ulrike Eggert– Dana Farber Cancer Institute, Boston, USA



"A combined chemical genetic/RNAi approach to study cell signalling"


12.00 - 12.35

Christie Sers– Charité Universitätsmedizin Berlin, Germany 



"Systems biology in predictive medicine"


12.35 - 13.25

Lunch/Trade exhibit


Poster Session 2



13.25 - 14.25

Authors of odd numbered posters in attendance


Session 6 - Protein complexes and protein-protein interaction networks


Chairperson: Tony Ng


14.25 - 15.00

Andrew Emili University of Toronto, Toronto, Canada



"Interaction networks and chromatin-related protein complexes in cancer"


15.00 - 15.35

Walter Kolch– Systems Biology Ireland, Dublin, Ireland



“Signalling networks and systems biology”


15.35 - 16.10

Michael Cusick – Dana-Farber Cancer Institute, Boston, USA


  "Interactome networks & human disease"  

16.10 - 16.40

Coffee/Trade exhibit


16.40 - 17.15

Igor Stagljar University of Toronto, Canada



"Protein interaction networks regulating cell signalling in cancer"


17.15 - 17.40

Proferred Talk 12: Anthony Coolen –King's College London, United Kingdom



“Non-equilibrium statistical mechanics of signalling in large protein interaction networks”



 Conference Dinner and Entertainment



Thursday 23rd June 2011


Session 7 - Data integration II – global views of cancer processes


Chairperson: Rolf Apweiler



Søren Brunak– Technical University of Denmark, Kongens Lyngby, Denmark



“Integrating healthcare sector data with molecular data in cancer”



Anne-Lise Børresen-Dale – The Norwegian Radium Hospital, Oslo, Norway



"Integrated genomics of breast cancer"



Coffee/Trade exhibit



Aedin Culhane Dana-Farber Cancer Institute, Boston, USA



“Computational Discovery of the Hallmarks of Cancer through Meta Gene Set Analysis”



Lodewyk Wessels – Netherlands Cancer Institute, Amsterdam, The Netherlands



“Oncogenic pathway identification through itegration of diverse, same sample data sources”



Lunch/Trade exhibit


Session 8 - Connecting systems approaches to commercial and clinical use


Chairperson: Stephen Pennington



Serhiy Souchelnytskyi – Karolinska Biomics Center, Stockholm, Sweden



"Personalized medicine and cancer proteomics"



Tony Ng - King's College London, UK
“Use of nanoscopic cancer tissue imaging, gene bioinformatics and mathematical modelling to predict the metastatic outcome of breast cancer sufferers“



Proferred Talk 13: Steven Kornblau – U. Texas M.D. Anderson Cancer Center, Houston, USA



“Proteomic analysis of the signaling pathways underlying acute myeloid leukemia”



Coffee/Trade exhibit



William Gallagher – University College Dublin, Dublin, Ireland
“Bridging the translational divide: converting omic datasets into clinical relevant assays”



Closing Keynote Lecture: Dario Neri – Institute of Pharmaceutical Sciences ETH Zurich, Switzerland



"Vascular tumor targeting: from target discovery to clinical trials"



Closing Remarks (William Gallagher)



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