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Conference Series

European Molecular Biology Organization

Programme

** POSTER FORMAT:

The size of a single poster should be no more than 1m (horizontal) x 1.50m (vertical).

Tuesday, September 22

13:00 – 20:00            Registration
18:00 - 20:00             Refreshments
20:00 – 22:00            Dinner

The Young Investigator’s Award will be sponsored by: ENZO LIFE SCIENCES (UK) LTD

Wednesday, September 23

8:00 – 9:00

Breakfast

PLENARY SESSION I: Components of the Ubiquitin System
Chair: Ron Kopito

9:00 – 9:10	Opening Remarks
9:10 – 9:40	Dan Finley Harvard Medical School, Boston/USA Chaperone-mediated assembly of the proteasome regulatory particle
9:40 – 10:10	Keiji Tanaka: Tokyo Metropolitan Institute of Medical Science, Fukuoka/Japan Molecular assembly and diversity of proteasomes
10:10 – 10:40	Mark Hochstrasser Yale University, New Heaven/USA Regulation and assembly of the proteasome
10:40 – 11:10	Coffee break
11:10 – 11:25	Shigeo Murata University of Tokyo, Tokyo/Japan Proteasome assembly in mammals
11:25 – 11:40	Michael Glickman Technion, Haifa/Israel Together, two ubiquitin-binding proteins, Rpn10 and Dsk2, can serve as a polyubiquitin chain-length sensor
11:40 – 12:10	Thorsten Hoppe EMBO Young Investigator Lecture CECAD Cologne at the Institute for Genetics, Cologne/Germany Ubiquitin chain editing modulates protein homeostasis and aging
12:10 – 12:25	Alexander Buchberger University of Wuerzburg, Wuerzburg/Germany Molecular basis of Ufd2 cofactor binding to Cdc48
12:25 – 12:40	David Komander MRC Laboratory of Molecular Biology, Cambridge/UK Structure, assembly and disassembly of Lys11-linked polyubiquitin chains
12:40 – 14:00	Lunch
14:00 – 14:30	Poster Setup

PLENARY SESSION I (continued): Components of the Ubiquitin System
Chair: Ron Kopito

16:00 – 16:30	Christopher Lima Sloan-Kettering Institute, New York/USA Structure and function in the SUMO pathway
16:30 – 17:00	Brenda Schulman St. Jude Children's Research Hospital/HHMI, Memphis/USA Mechanistic insights into a cullin-RING ligase
17:00 – 17:30	Hermann Schindelin University of Wuerzburg, Wuerzburg/Germany The structural basis of the interactions between p97/Cdc48 and its cofactors
17:30 – 18:00	Coffee break

PLENARY SESSION II: Ubiquitin and DNA

Chair: Christopher Lima

18:00 – 18:30	Helle Ulrich Cancer Research UK London Research Institute, London/UK Assembly and function of polyubiquitin chains in DNA damage bypass
18:30 – 19:00	Dana Branzei Institute of Molecular Oncology foundation [IFOM], Milano/Italy Crosstalk between SUMO, ubiquitin and checkpoint regulatory pathways in promoting recombination-mediated damage bypass of lesions
19:00 – 20:00	Dinner
20:00 – open end	Poster Session I (with Bar)

Thursday, September 24

8:00 – 9:00

Breakfast

PLENARY SESSION II (continued): Ubiquitin and DNA
Chair: Christopher Lima

9:00 – 9:30

Allan D’Andrea

Dana-Farber Cancer Institute, Boston/USA

The regulated ubiquitination and deubiquitination of FANCD2 in the Fanconi Anemia pathway

9:30 – 9:45

Sigurd Braun

University of California, San Francisco [UCSF], San Francisco/USA

A new role for the conserved Cul4-Ddb1-Cdt2 ubiquitin ligase complex in heterochromatic gene silencing in S. pombe

9:45 – 10:00

Catherine Dargemont

Institut Jacques Monod/CNRS/PARISVII, Paris/France
Ubiquitin and UBA domains: new players in the regulation of mRNA biogenesis

PLENARY SESSION III: Quality Control
Chair: Brenda Schulman

10:30 – 11:00	Randy Hampton UCSD Biological Sciences, California/USA Recognition and regulation of the Hrd1 E3 ligase
10:30 – 11:00	Coffee break
11:00 – 11:15	Ernst Jarosch Max Delbrueck Center for Molecular Medicine (MDC), Berlin, Germany Usa1 functions as a scaffold of the HRD-ubiquitin ligase
11:15 - 11:45	Ron Kopito T12 Stanford University, Stanford/USA Mapping the functional mammalian ERAD interactome
11:45 – 12:15	Jeffery Brodsky University of Pittsburgh, Pennsylvania/USA The selection and ubiquitination of ERAD substrates
12:15 – 12:45	Allan Weissman National Cancer Institute-USA, Frederick/USA Catching UBC on the flip side: insights into E3 function
12:45 – 13:00	Antje Schäfer Institute of Biochemistry, University of Stuttgart, Stuttgart/Germany Sec61p is part of the ERAD machinery
13:00– 14:00	Lunch
14:00 – 14:30	Poster Setup

PLENARY SESSION IV: Ubiquitin and Cell Cycle
Chair: Marc Hochstrasser

16:00 – 16:30	Michael Rape UC Berkeley, Berkley/USA Chaining ubiquitin to the spindle
16:30 – 17:00	Michele Pagano Howard Hughes Medical Institute/NYU School of Medicine, New York/USA Role of human F-box proteins in controling the proliferation of normal and cancer cells
17:00 – 17:30	Coffee break
17:30 - 17:45	Sara Sigismund Institute of Molecular Oncology foundation [IFOM], Milan/Italy A threshold effect in the ubiquitination of EGFR differentially couples the receptor with signaling or degradation
17:45 – 18:00	Neil Hattersley ST5 University of Dundee, Dundee/UK The SUMO protease SenP6 is required for chromosome alignment in mitosis
18:00 – 18:15	Antonio Iavarone ST6 Columbia University Medical Center, New York/USA The ubiquitin ligase Huwe1 regulates proliferation and neurogenesis by suppressing a N-Myc-DLL3-Notch pathway in neural stem cells
18:15 – 18:45	Hemmo Meyer T15 ETH Zurich, Zurich/Swiss The ubiquitin-dependent chaperone Cdc48/p97(Ufd1-Npl4) regulates Aurora-B kinase on mitotic chromosomes
18:30 – 19:00	Hemmo Meyer
19:00 – 20:00	Dinner
20:00 – 22:00	Poster Session II

Friday, September 25

8:00 – 9:00

Breakfast

PLENARY SESSION V: Ubiquitin like Proteins
Chair: Dan Finley

9:00 – 9:30	Matthias Peter T17 Institute of Biochemistry, HPM G8, Zurich/Swiss Function and regulation of cullin-based E3 ligases
9:30 – 10:00	Heran Darwin T4 New York University School of Medicine, New York/USA „Pupylation" in Mycobacterium tuberculosis
10:00 – 10:30	Frauke Melchior T14 ZMBH, University of Heidelberg, Heidelberg/Germany Two functionally non-equivalent Ubc9 molecules are required for sumoylation by the RanBP2/RanGAP1* SUMO1/Ubc9 E3 ligase complex
10:30 – 10:45	Marcus Groettrup University of Constance, Constance/Germany The ubiquitin-like modifier FAT10 in aggresomes, autophagosomes, and neurodegenerative diseases
10:45 – 11:15	Coffee break

PLENARY SESSION VI: Ubiquitin in Signaling and Regulation
Chair: Ron Hay

11:15 – 11:45	Yinon Ben-Neriah Hebrew University, Jerusalem/Israel Spermatogenesis rescue in a mouse deficient for the ubiquitin ligase SCF-beta-TrCP by single substrate depletion
11:45 – 12:15	Aaron Ciechanover Rappaport Faculty of Medicine and Research Institute, Haifa/Israel Regulation of the regulators or how components of the ubiquitin system are targeted for degradation
12:15 – 12:45	Yosef Yarden T23 Weizmann Institute, Rehovot/Israel Post-translational modifications and transcriptional loops in control of oncogenic signals
13:00 – 14:00	Lunch
14:00 – 14:30	Poster Setup
	Free afternoon Boat trip on Lake Garda or free disposal

19:00 – 20:00

Dinner

The Young Investigator’s Award sponsored by

ENZO LIFE SCIENCES (UK) LTD

20:00 – 22:00

Poster Session III

Saturday, September 26

8:00 – 9:00

Breakfast

PLENARY SESSION VI (continued): Ubiquitin in Signaling and Regulation
Chair: Ron Hay


9:00 – 9:30	Ivan Dikic Goethe University, Frankfurt/Germany Molecular basis of selective autophagy
9:30 – 9:45	Stefan Müller ST9 Max Planck Institute of Biochemistry, Martinsried/Germany Phospho-regulated SUMO interaction modules connect the SUMO system to CK2 signaling
9:45 – 10:00	Dirk Siepe ST12 Max Planck Institute of Biochemistry, Martinsried/Germany Pin1 acts as a fate switch by controlling the degree of substrate ubiquitylation
10:00 – 10:30	Sylvie Urbe T22 University of Liverpool, Liverpool/UK Ubiquitin dynamics in signalling and trafficking of growth factor receptors
10:30 – 11:00	Coffee break
11:00 – 11:30	Maria Masucci Karolinska Institutet, Stockholm, Sweden ???
11:30 – 11:45	Kazuhiro Iwai ST7 Osaka University, Suita/Japan Linear polyubiquitination : a newly identified regulator of NF-kappaB signaling
11:45 – 12:15	Wade Harper T7 Harvard Medical School, Boston/USA Genetic and proteomic analysis of the ubiquitin system
	Lunch
14:00	Departure

European Molecular Biology Organization | Meyerhofstrasse 1 | 69117 Heidelberg | Germany

practical courses | workshops | conference series | world activities | joint activities | plenary lectures|

Conference Series

European Molecular Biology Organization

UBIQUITIN AND UBIQUITIN–LIKE

MODIFIERS IN HEALTH AND DISEASE

Programme