Programme (FINAL)
*** UPDATE - Latest Programme to download (word.doc) |
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16:00 |
ARRIVAL/REGISTRATION |
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18:30 |
WELCOME AND OPENING REMARKS |
Harm H. Kampinga |
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19:00 |
KEYNOTE LECTURE 1: |
F. Ulrich Hartl |
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20:00 |
BUFFET/DRINKS/GET TOGETHER |
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SUNDAY |
07:30 |
BREAKFAST |
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08:30-10:30 |
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08.30 |
Pathways of Protein Folding and Quality control in the eukaryotic cytosol |
Judith Frydman |
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09.00 |
The catalytic properties of DnaK/DnaJ/GrpE as an ATP-fuelled unfoldase chaperone system. |
Peter Goloubinoff |
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09.15 |
Monitoring Protein Conformation along the Pathway of Chaperonin-Assisted Folding |
Kausik Chakraborty |
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09:30 |
Bimodal protein solubility distribution revealed by an aggregation analysis of the entire ensemble of Escherichia coli proteins |
Hideki Taguchi |
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09:45 |
Biogenesis of mitochondrial intermembrane space proteins - the MIA pathway |
Agnieszka Chacinska |
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10:00 |
Functions and mechanisms of ribosome-associated chaperones |
Elke Deuerling |
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10:30 |
COFFEE/TEA BREAK |
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11:00 – 13:00 |
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11:00 |
J-proteins/Hsp70s: versatile molecular chaperone machines |
Elisabeth Craig |
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11:30 |
A comprehensive view of allostery in the Hsp70 chaperone proteins. |
Erik Zuiderweg |
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11:45 |
Novel insight into the mechanism of chaperonin-assisted folding of the bacteriophage T4 capsid protein |
Saskia vd Vies |
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12:00 |
Chaperone-assisted assembly: The Rubisco paradigm |
Manajit Hayer-Hartl |
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12:15 |
Motor mechanism for protein threading through Hsp104 |
Petra Wendler |
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12:30 |
Hsp104 and the [PSI+] prion in budding yeast |
Helen Saibel |
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13:00 |
LUNCH |
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14:00 - 17:30 |
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17:30 19:00 |
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17:30 |
Ancient origin and functional differentiation of diverged chaperonin genes in eukaryotes |
Krishanu Mukherjee |
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17:45 |
The Chaperone Heat Shock Protein 70 and the Antioxidant Manganese Superoxide Dismutase are upregulated in chronic heat stress through p38MAPK and Akt |
Sanghamitra Raha |
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18:00 |
Regulation of envelope responsive CpxR/A and RpoE signal transduction pathways in response to LPS structural alteration in Escherichia coli |
Satish Raina |
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18:15 |
The plant heat-shock response is controlled by specific temperature-sensitive calcium-permeable channels in the plasma membrane. |
Andrija Finka |
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18:30 |
Stress response from membranes and back to membranes: lipid rafts at the crossroad |
Laszlo Vigh |
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19:00 |
DINNER |
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21:00-22:00 |
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21:00 |
Understanding the Mechanism by which Small Heat Shock Protein Activity is Regulated |
Andrew Aquilina |
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21:15 |
Thermo-dynamic regulation of small heat shock protein function: mass spectrometry reveals structural and dynamical details of these chaperones and the complexes they form with unfolding client proteins. |
Justin Benesch |
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21:30 |
The Ying and Yang of Oxidative Protein Unfolding |
Ursela Jacob |
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Monday |
07:30 |
BREAKFAST |
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08:30-10:30 |
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08.30 |
Can we exploit failures of homeostasis in the UPR? |
David Ron |
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09.00 |
The Anatomy of a Cellular Folding Compartment |
Maya Schuldiner |
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09:15 |
Chaperones and proteases as essential mediators of mitochondrial protein homeostasis |
Wolfgang Voos |
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09:30 |
Signaling through the Unfolded Protein Response |
Eelco van Anken |
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10:00 |
Protein folding in the endoplasmic reticulum |
Ineke Braakman |
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10:30 |
COFFEE/TEA BREAK |
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11:00 – 13:00 |
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11:00 |
Ubiquitilation of a group of ERAD substrates occurs on non-lysine, non-N-terminal, and non-cysteine residues |
Linda Hendershot |
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11:30 |
Misfolding and rescue of deltaF508 CFTR starts in NBD1 |
Hanneke Hoelen |
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11:45 |
Different ER quality control check-points mediate normal and abnormal P0 maturation |
Elisa Tinelli |
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12:00 |
The antibiotic ADEP reprograms ClpP, switching it from a regulated to an uncontrolled protease |
Janine Kirstein |
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12:15 |
Towards an understanding of the N-end rule pathway in Escherichia coli |
David Dougan |
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12:30 |
Cellular quality control of protein aggregates |
Bernd Bukau |
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13:00 |
LUNCH |
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14:00 - 17:30 |
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17:30 – 19:00 |
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17:30 |
Analyzing the physiological importance of chaperone-assisted degradation |
Joerg Hoefeld |
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17:50 |
Title to be announced |
Ai Yamamoto |
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18:10 |
HspB8 participates in protein quality control by a non chaperone-like mechanism that requires eIF2 alpha phosphorylation |
Serena Carra |
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18:30 |
Chaperone-mediated autophagy in Aging and Disease |
Ana Maria Cuervo |
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19:00 |
DINNER |
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21:00 – 22:00 |
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21:00 |
Chaperone assisted degradation of misfoldedcytoplasmic protein requires the ubiquitinligase Ubr1 (poster #116) |
Frederik Eisele |
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21:15 |
Immune complexes of glucose-regulated protein94 (grp94) with IgG are present in the plasma of type 1 diabetic subjects and show strong angiogenic-transforming capacity on huvecs (poster #128) |
Elisa Tramentozzi |
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21:30 |
Oligosaccharide Processing Dependent Tagging of Misfolded Proteins for ER Associated Degradation (poster #113) |
Edward Avezov |
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21:45 |
Role of ERAD substrate topology in selection of E3 ubiquitin ligases (poster #114) |
Riccardo Bernasconi |
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| 22:00 | Free | ||
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Tuesday |
07:30 |
BREAKFAST |
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08:30-10:45 |
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08.30 |
Protein Misfolding and Disease: From the Test Tube to the Organism |
Chris Dobson |
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09.00 |
Globally Monitoring Protein Translation One Codon at a Time |
Jonathan Weismann |
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09:30 |
Structural reorganisation and potential toxicity of oligomeric species formed during the assembly of amyloid fibrils |
Giorgio Favrin |
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09:45 |
Alpha-synuclein amyloid assembly is suppressed by the binding of alphaB-crystallin to mature fibrils |
Sarah Meehan |
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10:00 |
Hsp104 targets multiple intermediates on the pathway of amyloid formation |
Valerie Grimminger |
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10:15 |
The determinants of protein aggregation in vitro and in vivo |
Fabricio Chiti |
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10:45 |
COFFEE/TEA BREAK |
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11:15 – 13:00 |
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11:15 |
Epigenetics in Correction of Misfolding Disease |
William Balch |
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11:45 |
Molecular chaperone manipulation of SOD1 mediated motor neuron degeneration. |
Michael Cheetham |
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12:00 |
DnaJB and HSPB proteins, polyglutamine diseases and ageing |
Harm H. Kampinga |
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12:15 |
Destabilizing protein polymorphisms modulate proteotoxicity in models of conformational diseases |
Tali Gidalevitz |
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12:30 |
Proteostasis |
Jeff Kelly |
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13:00 |
LUNCH |
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14:00 - 17:30 |
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17:30 – 19:30 |
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17:30 |
Cellular modulators of polyglutamine aggregation |
Ann Bertolotti |
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18:00 |
Hsp40 family members reduce aggregation of pure polyglutamine peptides |
Judith Gillis |
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18:15 |
The ataxia protein sacsin is a functional cochaperone that can protect against polyglutamine expanded protein |
David Parfitt |
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18:30 |
Involvement of chaperone system in the destruction of amyloid structures |
Irina Naletova |
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18:45 |
Elucidating aggregation pathways in a C. elegans model for alpha-synuclein inclusion formation |
Annemieke van der Goot |
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19:00 |
Prion maturation in yeast |
Jens Tyedmers |
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19:15 |
Molecular Chaperones and the propagation of the yeast prions [URE3] and [PSI+] |
Ronald Melki |
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19:30 |
DINNER |
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21:00 – 22:30 |
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21:00 |
Rescue of folding defects in fatty acid metabolic disease: role of flavin cofactors and a molecular rationale for vitamin B2 effects |
Claudio Gomes |
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21:15 |
Oxido-reductive Stress in Protein Aggregation Disorders |
Ivor Benjamin |
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21:45 |
An unfolded CH1 domain controls the assembly and secretion of murine IgG1 antibodies |
Mattias Feige |
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22:00 |
Heat shock proteins are targets for T-cell regulation in chronic inflammatory diseases |
Willem van Eden |
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Wednesday |
07:30 |
BREAKFAST |
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08:30-10:30 |
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08.30 |
Functional genomics of the Hsp90 machine in yeast and mice |
Didier Picard |
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09.00 |
Hsp90-binding TPR proteins regulate the subcellular localization of nuclear factors |
Mario Galigniana |
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09.20 |
The conformational dynamics of the Hsp90 chaperone machine |
Matthias Mayer |
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09:40 |
Tissue-specific functions of the Hsp90 chaperone network in C. elegans (poster requested). |
Patricija van Oosten-Hawle |
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10:00 |
Conformational regulation of Hsp90 |
Johannes Buchner |
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10:30 |
COFFEE/TEA BREAK |
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11:00 – 11:45 |
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11:00 |
Role of Heat Shock Proteins in Oncogene-induced Senescence |
Michael Sherman |
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11:30 |
The cooperation of Hsp90 and Hsp70 in the chaperoning of wild-type p53 ((poster requested) |
Dawid Walerych |
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11:45 |
Suppression or progression: context-dependent activity of p53. |
Majiec Zylicz |
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12:15-13:00 |
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13:00 |
LUNCH |
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14:30 – 17:00 |
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14:30 |
Beneficial effects of small mitochondrial chaperones on aging: a trade-off with cancer |
Robert Tanquay |
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15:00 |
Stress Responses and Proteostasis Networks in Ageing and Neurodegenerative Disease |
Rick Morimoto |
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15:30 |
Protein aggregation as an inherent part of ageing |
Della David |
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15:50 |
Mitotic arrest in response to the accumulation of misfolded protein: a protein homeostasis checkpoint |
Sebastian Treusch |
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16:10 |
Inactivation of a small-EDRK-rich factor suppresses amyloid inclusion formation and promotes longevity in a C. elegans model for age-related diseases |
Ellen Nollen |
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16:30 |
Reduced IGF-1 Signaling Delays Alzheimer’s-like Disease Progression in Mice |
Andy Dillin |
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17:00 - 17:30 |
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19:30 |
DINNER AND BEACH-PARTY |
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Thursday |
07:30 |
BREAKFAST |
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DEPARTURE |
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