Programme
Setpember: 12 | 13| 14| 15| 16 |
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14:00-18:30 |
Registrations |
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18:30 |
Welcome cocktail |
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19:00 |
Dinner |
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20:45-21:00 |
Welcome remarks |
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21:00-21:45 |
Keynote address: "How Aire impacts on transcription to drive immunological tolerance." |
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22.30 |
Shuttle for participants lodged in Siena |
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9:00-10:45 |
Session 1 Chairperson: Art Weiss Initiation of TCR signaling in immature and naive T cells |
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9:00 - 9:30 |
Ed Palmer "How the TCR reads ligand affinity" |
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9.30 - 10:00 |
Arup Chakraborty "How T cells see antigen" |
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10:00 - 10:30 |
Mark Davis "TCR interactions within the synapse" |
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10:30 - 10:45 |
Jane Oliaro "Asymmetric cell division orchestrates differentiation of effector and memory T cells" |
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10:45-11:15 |
Coffee break |
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11:15-12:45 |
Session 2 Chairperson: Dan Littman Orchestration of TCR signaling in naive T cells |
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11:15 - 11:45 |
Nicholas Gascoigne “Themis controls thymocyte selection through regulation of T cell receptor-mediated signaling” |
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11:45 - 12:15 |
Larry Samelson "Signaling at the TCR" |
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12:15 - 12:45 |
Cosima T. Baldari "Unexpected role of intraflagellar transport at the immunological synapse" |
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13:00 |
Lunch |
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15:00-18:30 |
Poster session |
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19:00 |
Dinner |
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20:30-21:15 |
New paradigms keynote: "Structure, reaction dynamics and spatial organization of cellular signalling networks" |
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21:15-22:15 |
Session 3 Chairperson: Steve Reiner Signals regulating lymphocyte adhesion and migration |
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21:15 - 21:45 |
Doreen Cantrell "Different PI3K/Akt signaling thresholds control T cell migration versus proliferation" |
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21:45 - 22:00 |
Jennifer Cannons " Integration of adhesive pathways: role for integrins and SLAM family members in T:B cell interactions " |
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22:00 - 22:15 |
Stephen Bunnell "VLA-4 Ligation Retards the Centripetal Movement of the Myosin-Dependent Contractile Rings Responsible for the Centralization of SLP-76 Microclusters" |
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22:40 |
Shuttle for participants lodged in Siena |
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9:00-10:30 |
Session 4 Chairperson: Meinrad Busslinger Orchestration of BCR signaling in immature and naive B cells |
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9:00 - 9:30 |
John Cambier "ITAMs as molecular switches driving anergy versus activation" |
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9:30 - 10:00 |
Facundo Batista “Interplay between the BCR and cytoskeleton: a mechanism to regulate lymphocyte activation and tonic signaling?” |
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10:00 - 10:30 |
Hassan Jumaa “Role of pre-BCR signaling in early B cell development” |
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10:30-11:00 |
Coffee break |
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11:00 - 12:30 |
Session 5 Chairperson: Doreen Cantrell Orchestration of TCR signaling in effector T cells |
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11:00 -11:30 |
Andrew Chan "Control of T cell effector functions through the cytoskeleton" |
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11:30 - 12:00 |
Steve Reiner "Inducing the cell fates required for immunity" |
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12:00 - 12:15 |
Salvatore Valitutti "PKCζ activation at the immunological synapse guides T cell help delivery"" |
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12:15 - 12:30 |
Andres Alcover "Cytoskeletal crosstalk in the control of T cell receptor signaling" |
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12:45 |
Lunch |
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14:30 - 15:45 |
Session 6: Imaging the immune response |
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14:30 - 15:00 |
Ron Germain "In Situ Dynamics of T Cell Co-operation and Effector Activation Analyzed By 2 Photon Microscopy" |
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15:00 - 15:30 |
Philippe Bousso "Dynamics of T cell and NK cell activation in vivo" |
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15:45 |
Shuttle to Siena, free afternoon and/or guided tour in Siena. Dinner at a local restaurant |
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9:00-10:30 |
Session 7 Chairpersons: Ed Palmer Effectors in TCR signaling |
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9:00 - 9:30 |
Balbino Alarcon "Role of the GTPase TC21 in antigen receptor homeostatic signaling" |
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9:30 - 10:00 |
Art Weiss "A chemical-genetic approach towards turning T cells on and off with small molecules" |
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10:00 - 10:15 |
Mira Barda-Saad "Studying the Molecular Complex Formation Consisting of SLP-76, Nck and VAV Critical for the Immune Response" |
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10:15 - 10:30 |
Margot Thome "TCR-induced NF-kB activation: the role of MALT1" |
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10:30-11:00 |
Coffee break |
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11:00 - 13:00 |
Session 8 Chairpersons: John Cambier Effectors in BCR signaling |
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11:30 - 12:00 |
Tomo Kurosaki "Role of PLCg2 in humoral memory responses" |
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12:00-12:15 |
Lakshmi Srinivasan "PI3- Kinase signaling is responsible for BCR mediated mature B cell survival" |
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12:30-12:45 |
Roberta Pelanda "A recipe for B cell positive selection: a cup of tonic BCR signal, a tablespoon of Ras and a pinch of active Erk" |
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12:45-13:00 |
Brian Iritani " Identification of a novel metabolic regulator controlling B lymphocyte development" |
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13:15 |
Lunch |
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15:00-16:45 |
Session 9 Chaiperson: Gitta Stockinger Signaling in lymphocyte commitment and development |
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| 15:00-15:30 |
Meinrad Busslinger
"The role of STAT5 and IL-7 signaling during B cell commitment" |
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15:30-16:00 |
Gary Koretzky “Probing the molecular basis of adapter protein function” |
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16:00-16:30 |
Michael Dustin "Exclusion of protein kinase C-theta from regulatory T cell synapse and role in tuning suppression" |
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16:30-16:45 |
Grégoire Altan-Bonnet "Differential suppression of effector T cells by regulatory T cells derives from a highly-dynamic IL-2 tug-of-war" |
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16:45 - 17:15 |
Coffee break |
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17:15-18:45 |
Session 10 Chaiperson: Gary Koretzky Signaling in lymphocyte differentiation |
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17:15-17:45 |
Dan Littman "Transcriptional networks in T cell differentiation" |
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17:45-18:15 |
Gitta Stockinger "Modulation of immune responses via environmental signals and the aryl hydrocarbon receptor" |
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18:15-18:45 |
Federica Sallusto "Heterogeneity of human CD4+ memory T cells: functional modules for tailored immunity" |
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18:45 |
Concluding remarks |
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20:00 |
Banquet |
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22:00 |
Dance Party |
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22:00 AND 24:00 |
Shuttle for participants lodged in Siena |
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Departures |
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