Conference Series

European Molecular Biology Organization

NUCLEAR RECEPTORS:

 

from molecular mechanisms to molecular medicine

 


 

 

 

 

 

 



25 - 29 September | 2009 | Dubrovnik | Croatia

Programme

 

 

 

  ***  DOWNLOAD LIST HERE (pdf document)
   
  Poster session I. (Odd numbered posters):
26th September, 2009. 5.30 PM - 7.30 PM
Poster session II. (Even numbered posters):
28th September, 2009. 5.00 PM - 7.00 PM
   
  *list in numerical order
 

P1 Reichardt, Holger M
Control of neuroinflammatory diseases by glucocorticoids

 

P2 van Royen, Martin E.
Detailed analysis of nuclear receptor dynamics by single-molecule microscopy

 

P3 Schmidt, Daniel

Regulation of bile acid synthesis by the vitamin D receptor

 

P4 Aranda, Ana
Role of the thyroid hormone receptor β1 and hypothyridism in tumor growth,   invasiveness and formation of metastasis

 

P5 Fon Tacer
Klementina Expression atlas of the fibroblast growth factor system in adult mouse organs

 

P6 Castellano, Leandro
The estrogen receptor-alpha induced micro RNA signa

 

P7 Haegeman, Guy

Compound A, a fully dissociated compound of plant origin for inflammatory gene repression,  does not lead to glucocorticoid insensitivity.

 

P8 Modica, Salvatore
Selective actvation of intestinal nuclear bile acid receptor FXR protects from cholestatis

 

P9 Diwo, Janine
Pro- and anti-inflammatory actions of LXRS by regulating members of the interleukin 1 family

 

P10 Aranyi, Tamas

Transcriptional regulation of the human ABCC6 gene

 

P11 Jamnongjit, Michelle
Mice with an Inducible, Smooth Muscle Cell-Specific Deletion of Estrogen Receptor α Exhibit  Loss of Estrogen Protection in Response to Vascular Injury

 

P12 Ehrlund, Anna
Molecular mechanisms of steroidogenic gene regulation by the orphan receptors   SF-1 and DAX-1

 

P13 Giamas, Georgios
Effects and functional consequences of estrogenic and anti-estrogenic compounds on AIB1   protein levels in pancreatic tumor cell lines

 

P14 Tomaszewska, Aleksandra
RNA species dynamics: Combining experiments and systems biology modeling

 

P15 Lenfant, Francoise
Prevention of skin flap necrosis by estradiol involves reperfusion of a protected vascular   network

 

P16 Markov, Gabriel
Independent elaboration of steroid hormone signaling pathways in Metazoans.

 

P17 Caelles, Carme
Anti-diabetic and anti-inflammatory actions of TZD/PPARγ by inhibition of the JNK pathway.

 

P18 Bloch, Mandy
HMGA1 - a new regulator of PPARgamma-mediated transrepression in human aortic   smooth muscle cells

 

P19 Lobo, Glenn Prazere
Evidence for a specific role of β-carotene in influencing nuclear receptor activities involved in  the regulation of lipid metabolism

 

P20 Hoang, Tuyen
The role of PKA and CREB in regulation of the steroid receptor coactivator GRIP1/SRC-2

 

P21 Watanabe, Mitsuhiro
Influence of FXR activation in the metabolic control

 

P22 Ruijtenbeek, Rob

Detection of multiple nuclear receptor–coregulator interactions in a single sample using   MARCoNI PamChip technology

 

P23 Fenne, Ingvild S.
Role of the CAMP-PKA signaling pathway in the regulation ERa-dependent transcription by  steroid receptor coactivators in breast cancer cells.

 

P24 Matic, Marko
An in vivo approach to investigating the sub-cellular distribution of nuclear receptors.

 

P25 Flågeng, Marianne
Hauglid HER-2/neu and nuclear receptor coactivators are upregulated in breast cancer tumors during  estrogen deprivation

 

P26 Berriel Diaz, Mauricio
The nuclear receptor cofactor RIP140 is crucial for the pro-inflammatory response in primary  murine hepatocytes

 

P27 Houtman, René
MARCoNI: ex-vivo functional analysis of full length ERα in crude lysates of cell lines and   patient material

 

P28 Gacias Monserrat, Mar

FoxO1 is a co-repressor of PPARα on the Cpt1b promoter.

 

P29 Macejova, Dana
Effects of vinclozolin, Bisphenol A and genistein on retinoid nuclear receptors expression in  primary human hepatocytes

 

P30 Karin, Tamm
Target genes for estrogen and progesterone receptors in human endometrium cell lines   HEC1A and RL95-2

 

P31 Relat, Joana
MyoD and PPARa activate the CPT1B promoter

 

P32 De Sousa-Coelho, Ana Luísa
RoleOF SIRT1 on the PPARα mediated regulation of the β-oxidation and ketogenesis

 

P33 Eskild, Winnie
Regulation of VEGF expression by vitamin D in hepatic stellate cells – possible attenuation by  the nuclear receptor coregulator NCU-G1.

 

P34 Paulsen, Steinar Martin
Discovery of drugs candidates from marine organisms to treat metabolic diseases

 

P35 Ohmayer, Susanne
The role of RORα and p63 in keratinocyte differentiation

 

P36 Martins, Joana
Glucocorticoid regulation of mouse and human dual specificity phosphatase 1 (DUSP1) Genes:  unusual CIS-acting elements and unexpected evolutionary divergence.

 

P37 Romano, Andrea
Co-regulator recruitment by estrogen receptor-β correlates with cell and gene specific   responses to 17β-estradiol and tamoxifen

 

P38 Ondkova, Slavomira
Nuclear thyroid hormon receptors and their coregulators: Effects of vinclozolin, bisphenol   A and genistein in both human primary hepacotcytes and MCF-7 cells

 

P39 Perelli, Roberta
Cell density modulates transcriptional responses to glucocorticoids in a gene-specific manner.

 

P40 Vila Brau, Anna
HMGCS2 plays a critical role in PPARα fatty acid oxidation induction

 

P41 Tijanic, Tamara
Progesterone modulation of osteopontin expression in early pregnancy

 

P42 Heldring, Nina
Estrogen Receptor-Mediated Transcription Through the Activating Protein-1-Dependent  “Tethering” Pathway involves a host of factors

 

P43 Kacevska, Marina
Extra-hepatic cancer impairs hepatic drug metabolism through interference with nuclear   receptor signalling.

 

P44 Krstic-Demonacos, Marija
The role of the glucocorticoid receptor phosphorylation in regulation of Bcl 2 family

 

P45 Gadaleta, Raffaella Maria

A novel role of FXR in intestinal inflammation?

 

P46 Andò, Sebastiano
Androgen receptor regulation of the cyclin D1 gene through an androgen response element in  the proximal promoter.

 

P47 Louw, Ann
Phytoestrogenic activity of Cyclopia

 

P48 Billas, Isabelle M.L.
Structural studies of transcriptional complexes of homodimeric nuclear receptors involving ERR

 

P49 Arányi, Tamás
MethyLC : HPLC-MS/MS detection of DNA methylation by nucleobase ratio determination after   bisulfite PCR

 

P50 Ping, Quan
Non-genomic effects of estrogen on endometriosis

 

P51 Lo Sasso
Giuseppe Liver X Receptor Negatively Modulates Hepatocyte Regeneration Capacity After Partial   Hepatectomy.

 

P52 Pedraz, Elena
Analysis of the regulation of AACS expression by the nuclear receptor FXR

 

P53 Rizzo, Giovanni
INT-747: a Potent and Selective FXR Agonist Regulating Glucose Metabolism and Enhancing   Insulin Secretion

 

P54 Langlais, David
Regulatory interactions between GR and Stat3

 

P55 Jericevic, Zeljko
Bioinformatics study of nuclear receptor superfamily relation to UniProt data

 

P56 Jakobsson, Tomas
GPS2 is required for macrophage cholesterol efflux by facilitating histone H3 lysine 9   demethylation, LXR recruitment and coregulator assembly at the ABCG1 promoter/enhancer unit

 

P57 Talabér, Gergely
Mitochondrial translocation of the glucocorticoid receptor in double positive thymocytes and  its possible role in thymocyte apoptosis

 

P58 Ikeda, Kazuhiro
Nuclear receptors, FOX transcription factors and short RNAs regulated by estrogen in human  breast cancer MCF-7 cells and its tamoxifen-resistant clones.

 

P59 Conzen, Suzanne Daniela
Glucocorticoid receptor signaling in breast biology

 

P60 Cermenati, Gaia
Liver X Receptor activation affects testosterone and its metabolite levels in sciatic nerves   of adult male rats

 

 

 

P61 Andò, Sebastiano Farnesoid
X Receptor ligand CDCA inhibits growth of tamoxifen-resistant breast cancer cells.

 

P62 Jonker, Johan W.
Transcriptional regulation of the circadian circuitry by the nuclear receptor family

 

P63 Ansems, Marleen
DC-Script modulates nuclear receptor activity and is an independent prognostic marker   for breast cancer

 

P64 Tanaka, Toshiya
The peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha heterodimer   targets the histone modification enzyme PR-Set7/Setd8 gene and regulates   adipogenesis through a positive feedback loop.

 

P65 Moustafa, Tarek
FXR protects from bile acid toxicity and steatosis while its absence attenuates cholangitis   and biliary fibrosis caused by Mdr2 deficiency

 

P66 Aakula, Anna
Genome-wide functional analysis of microRNAs in prostate cancer

 

P67 Africander, Donita
Differential regulation of the RANTES gene by synthetic progestins used in contraception   and HRT

 

P68 Vainio, Paula
High-throughput screening for novel prostate cancer drug targets

 

P69 Germain, Pierre
New insights into molecular details of the determinants of both RAR subtype selectivity and  agonist/antagonist-induced structural changes

 

P70 Alexis, Michael N.
Estrogen Receptor Beta Isoforms 1 and 2 Differentially Modulate Growth and Invasiveness of  Breast Cancer Cells in Response to Estrogen and Antiestrogens

 

P71 Teyssier, Catherine
New insights into molecular details of the determinants of both RAR subtype selectivity and  agonist/antagonist-induced structural changes

 

P72 Vegeto, Elisabetta
Estrogen action in inflammation

 

P73 Stavreva, Diana
Atanassova Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene   transcription

 

P74 Dworatzek, Elke
Transcriptional activity of Matrix Metalloproteinase-2 is inhibited by 17-beta-Estradiol via   activation of MAP-Kinase pathway in fibroblast cells

 

P75 Pommier, Aurélien
Liver X receptors modulate lipid raft signaling in prostate cancer cells and xenografts

 

P76 Kintscher, Ulrich
Histone Deacetylase 6 - HDAC 6 - A New Regulator of Glucocorticoid Receptor-Mediated  Metabolic Processes

 

P77 Delphine, Duteil
The nuclear receptor coregulator TIF2 regulates energy homeostasis by controlling   mitochondrial activity in skeletal muscle myocytes.

 

P78 Grøntved, Lars
MED14 tethers the mediator to the N-terminal domain of PPARgamma and is required for full   transcriptional activity and adipogenesis

 

P79 Skaf, Munir
Molecular Dynamics Simulations of Nuclear Receptors

 

P80 Tzertzinis, George
Comparative analysis of elements controlling Dax-1 expression in mouse and human

 

P81 Neto, Goncalo Rere
(Atrophin2) controls retinoic acid signaling and somite bilateral symmetry

 

P82 Crambert, Gilles
Progesterone regulates renal potassium transport via activation of its nuclear receptor   expressd in kidney

 

P83 Moecklinghoff, Sabine
Phosphorylation of the ER Ligand Binding domain via protein semi-synthesis and its influence  on cofactor binding

 

P84 Andò, Sebastiano
Regulation of ER mediated transcription by AKT2/FOXO3A signalling in breast cancer cells

 

P85 Hall, Matthew
PPARbeta in astrocyte maturation and functions

 

P86 Simandi, Zoltan
Role of a nuclear receptor coactivator PRMT1 in embryonic stem cell differentiation

 

P87 Zelcer, Noam
LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor

 

P88 Varga, Tamas
Regulation of TAL1/SCL in dendritic cells by nuclear receptors

 

P89 Sardella, Chiara
Alteration of hair follicle differentiation and cycling in a mouse model of PPARγ deletion

 

P90 Young, Morag
Oxidative Stress Promotes Cortisol Activation of the Mineralocorticoid Receptor in the  Development of Cardiac Fibrosis

 

P91 Visser, Arie
Identification of a potent and selective cofactor binding inhibitor of ERα.

 

P92 Visser, Arie
Chip-based peptide recruitment profiling of estrogen receptor α ligands.

 

P93 Clyne, Colin

LRH-1 promotes motility and invasiveness of breast cancer epithelial cells

 

P94 Széles, Lajos
1,25-dihydroxyvitamin D3 is an autonomous regulator of the transcriptional changes leading  to a tolerogenic dendritic cell phenotype

 

P95 Bourguet, William
Modulation of nuclear receptor activity by organotin environmental endocrine disruptors

 

P96 Pourcet, Benoit
SUMOylation oh the human nuclear receptor PPARalpha inhibits its transactivity trough the  specific recruitment of NCoR

 

P97 Pap, Attila
The expression profile of the nuclear receptor superfamily in dendritic cells and macrophages

 

P98 Fuchs, Sascha
Chemical biology approaches for the estrogen receptor – coactivator interaction

 

P99 Poliska, Szilard
Single nucleotide polymorphisms of PPARγ predict preventive effects in chronic inflammatory  diseases

 

P100 Heery, David
Novel LXXLL motif variants required for binding of the BCL11A oncoprotein to COUP-TFII,  promoting a functional switch from activator to repressor

 

P101 Gyöngyösi, Adrienn
Potassium channel regulation by PPARγ in human Dendritic cells

 

P102 Héligon, Christophe
HDAC7 as a modulator of HNF4 transcriptional activity

 

P103 Misiti, Silvia
Thyroid hormone T3 protects the human ovarian granulosa cell line COV434 from apoptosis

 

P104 Bravics, Balazs
Investigation of the retinoic acid receptor mobility using in vivo fluorescence microscopy

 

P105 Watson, Peter
Characterization of the three-way interaction between SMRT, GPS2 and TBL1

 

P106 Kim, Seung-Whan
Characterization of ASC-2 as an Anti-Atherogenic Transcriptional Coactivator   of Liver X Receptors in Macrophages

 

P107 Fairall, Louise
Structural basis for the activation of PPARγ by oxidized fatty acids

 

P108 Aydin, Gamze
Lycopene and apo-lycopenoic acids are potent activators of RAR-mediated pathways in   RARE-luc mice

 

P109 Bartis, Domokos

Glucocorticoid receptor mediated non-genomic tyrosine phosphorylation of ZAP-70

 

P110 Gilardi, Federica
The new dual PPARalpha/gamma ligand LT175 improves glucose homeostasis and reduces fat  mass in a mouse model of diet-induced obesity (DIO)

 

P111 Galmozzi, Andrea
PGC-1α is a key player in the metabolic reprogramming induced by HDAC inhibitors in   myotubes.

 

P112 Sladek, Frances M.
HNF4alpha – a metabolic receptor with links to cancer

 

P113 Palijan, Ana
HDAC6 and CtBP contribute to LCoR regulation of nuclear receptor mediated transcription   repression

 

P114 Krust, Andrée
Abnormal sexual behaviour of male and female ERβ-null mice

 

P115 Gupta, Pawan
HDAC3 as a molecular chaperone for shuttling phosphorylated TR2 to PML: a novel deacetylase  activity-independent function of HDAC3.

 

P116 Dubrac, Sandrine
PXR modulates T-lymphocyte function.

 

P117 Antal, Maria Cristina
Sterility and absence of histopathological defects in nonreproductive organs of a mouse   ERβ-null mutant

 

P118 Hua, Guoqiang
New mechanism and function of ErbB2 nuclear receptor in breast cancer.

 

P119 Benoit, Gérard
Rev-erbα isoforms and Circadian Clock Regulation

 

P120 Kang*, Heonjoong
Developmental treatment of PPAR delta agonist was enough to increase physical endurance

 

P121 Altintas, Dogus
Cell Cycle Dependant Transcriptional Activation of Target Genes by Androgen Receptor in   Prostate Cells.

 

P122 Bilesimo, Patrice
Histone Demethylase and Thyroid Hormone Receptor Mecanism of Action.

 

P123 Wawrzyniak, Marta
Katarzyna PPAR involvement in adult vascular functions and angiogenesis

 

P124 Mani, Sridhar
Specific Interference with the Pregnane X Receptor reveals novel mechanisms of action of  cancer chemotherapy

 

P125 Ziouzenkova, Ouliana
Retinaldehyde dehydrogenase-1 regulates sex-specific formation of omental fat

 

P126 Wolfrum, Christian
Retinoic-related orphan receptor gamma controls adipogenesis and contributes to the   development of metabolic disorders

 

P127 Hurtado, Antoni
Transcriptional regulation of ERBB2 by estrogen receptor-PAX2 determines response to   tamoxifen

 

P128 Fuller, Peter
Identification of tesmin as a ligand-specific coactivator of the mineralocorticoid receptor

 

P129 Bonneton, François
Structural and evolutionary plasticity of interacting nuclear receptors

 

P130 Hong, Cynthia

LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor

 

P131 Ganti, Krishna
Priya Nuclear Receptor-mediated regulation of Thymic stromal lymphopoietin (TSLP) expression

 

P132 Rytinki, Miia Maria
Sumoylation attenuates the function of PGC-1α

 

P133 Martinez, Leandro
A molecular dynamics perspective on nuclear hormone receptor function

 

P134 Prenzel, Tanja
The ubiquitin-proteasome system controls nuclear hormone receptor activity in a time- and  gene-specific manner

 

P135 Sedlak, David
New steroid receptor reporter cell lines for high throughput profiling

 

P136 Ali, Faisal
Nuclear receptor PPARδ and its co-activator PGC1alpha act cooperatively to induce heme  oxygenase-1 and enhance vascular endothelial resistance to oxidative stress

 

P137 Rauch, Alexander
A critical role of the glucocorticoid receptor in myeloid cells in obesity linked insulin   resistance

 

P138 Baschant, Ulrike
Steroid therapy of rheumatoid arthritis depends on dimerization of the glucocorticoid   receptor in T cells

 

P139 Bai, Peter
Identification of poly(ADP-ribose) polymerase-2 as a cofactor of the RXR-PPARg transcriptional   machinery

 

P140 Lefebvre, Philippe Claude
Obesty-associated proteasomal degradation of RXRalpha leads to selevtive PPARgamma  modulation through perturbed corepressor interaction

 

P141 Antony, Pierre
Structure based-design of a novel superagonist ligand for the vitamin D nuclear receptor

 

P142 Ross-Innes, Caryn Sarah
Retinoic Acid Receptor-α is an essential component for Estrogen Receptor-mediated  transcription and cell growth

 

P143 Medina, Ana
Sancho DOR acts as a nuclear coactivator

 

P144 Kôhalmy, Krisztina
Dehydroepiandrosterone induces human CYP2B6 through the constitutive androstane receptor

 

P145 Pochetti, Giorgio
Partial agonism in PPARs: the role of the helix 3

 

P146 Koppen, Arjen
MARCoNI, a novel coregulator-nuclear receptor interaction assay, identifies TRIP3 as   a PPARγ coregulator

 

P147 Zhou, Changcheng
Activation of pregnane X receptor induces hypercholesterolemia in wild-type and accelerates  atherosclerosis in apolipoprotein E deficient mice

 

P148 Perez, Paloma
Glucocorticoid receptor in skin development

 

P149 Surapureddi, Sailesh
HNF4α associates RNA Pol II through Med25 to initiate CYP2C9 gene expression

 

P150 Anthonisen, Elin Holter
The Nuclear Receptor LXR is O-GlcNAc Modified in Response to Glucose

 

P151 Vanacker, Jean-Marc
Estrogens repress PGC-1α expression in the uterus

 

P152 Losciuto, Sophie
Regulation of the inflammatory state of microglia by Liver X Receptors.

 

P153 Welter-Stahl, Lynn
Liver X receptors modulate the differentiation of human macrophages

 

P154 Temesvári, Manna
Drug interaction potential of LK-935, the novel non-statin type cholesterol lowering agent

 

P155 Michalides, Rob
PKA-induced phosphorylation of ERα at serine 305 and/or high PAK1 levels predict tamoxifen  resistance in ER positive breast cancer.

 

P156 Kremoser, Claus
Massive lipid lowering, Anti-steatotic, and Anti-diabetic effect of a series of novel   FXR agonists

 

P157 Boyer, James
Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells via RXR   in addition to FXR dependent mechanisms

 

P158 Molnár, Ferdinand
Molecular mechanism of allosteric communication in the human PPARα-RXRα heterodimer

 

P159 Pfeifer, Thomas
Novel effects of an oxysterol derived LXR agonist on cholesterol metabolism in mice

 

P160 Francis, Víctor A. Bonobo
a new Ecdysone receptor coactivator

 

P161 Pandey, Deo Prakash
miR-22 inhibits estrogen signaling by directly targeting the estrogen receptor alpha mRNA.

 

P162 Barettino, Domingo
Proteomic analysis of phosphorylated nuclear proteins underscores novel roles for rapid   actions of Retinoic Acid in the regulation of mRNA splicing and translation.

 

P163 Privalsky, Martin L.
Alternative mRNA splicing of corepressors modifies their biological functions and helps   explain the dominant-negative properties of the x-RARα mutants found in human acute  promyelocytic leukemia.

 

P164 Williams, Cecilia
Mammary stem cell-like gene expression and nuclear receptors.

 

P165 Edvardsson, Karin
Anti-tumorigenic effects by ERb in three different human colorectal cancer cell lines

 

P166 Burgermeister, Elke
Expression and function of farnesoid X receptor in gastric cancer

 

P167 Deblois, Genevieve
Functional genomics analysis of ERα, ERRα and PGC-1β crosstalk in human breast cancer cells.

 

P168 Baniahmad, Aria
Wildtype but not mutant androgen receptor inhibits expression of the hTERT telomerase  subunit: A novel role of AR mutation for prostate cancer development

 

P169 Baniahmad, Aria
The natural compound atraric acid inhibits the human androgen receptor, cellular invasiveness  and prostate cancer cell growth

 

P170 Baniahmad, Aria
The peptide aptamer based corepressor T-Pep 513 inhibits prostate cancer cell growth

 

P171 Adzic, Miroslav
Chronic stress affects phosphorylation of glucocorticoid receptor in cytoplasm, nucleus and  mitochondria of Wistar rat brain

 

P172 Gauthier, Karine Cécile
The thyroid hormone receptor TRalpha: an unexpected anti atherosclerotic agent

 

P173 Venteclef, Nicolas
GPS2-dependent corepressor / SUMO pathways govern anti-inflammatory actions of LRH-1 and  LXRs in the hepatic acute phase response

 

P174 Chatzopoulou, Antonia
The functional role of the zebrafish glucocorticoid receptor beta-isoform

 

P175 De Bosscher, Karolien
PPARalpha activation not only enhances GRalpha-mediated pro-inflammatory gene repression,  but also prevents glucocorticoid-mediated hyperinsulinemia: a double gain.

 

P176 Pantoja, Carlos
Glucocorticoid signaling defines a novel commitment stage during adipogenesis in vitro

 

P177 Chakravarti, Debabrata
Novel roles of hormones and vitamins in integrating chromatin remodeling and nuclear  (Debu) receptor function

 

P178 Pan, YouFu
Cell-type specific transcriptional network of ERα in breast and uterine cancer

 

P179 Fontaine, Coralie
The transactivating function-1 of estrogen receptor alpha is dispensable for the   vasculoprotective actions of 17β-estradiol

 

P180 Hellemans, Karine
LXR-agonists protect primary beta cells against saturated fatty acids

 

 

 

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