Programme
August: 26 | 27 | 28 | 29 |
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14.00 – 17.00 |
arrival and registration |
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17.00 – 18.00 |
welcome |
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18.00 – 21.30 |
session 1 : chair: Brian McStay Dynamics of rDNA structure |
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18:00 - 18:10 |
Introduction |
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18.10 - 18.30 |
Joachim Griesenbeck: Biochemical characterization of DNAchromatin in S. cerevisiae |
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18.30 - 18.50 |
Ross Hannan: UBF-dependent but methylation-independent silencing and activation of rRNA genes during differentiation and malignant transformation |
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18.50 - 19.10 |
Brian McStay: The chromosomal context of human NORs |
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19.10 - 19.30 |
Craig Pikaard: Epigenetic mechanisms of uniparental rRNA gene silencing in hybrids: a role for RNA in nucleolar dominance |
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19.30 - 19.50 |
Break |
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19.50 - 20.10 |
Julio Sáez-Vásquez: In Arabidopsis thaliana plants with a disrupted nucleolin gene rRNA gene transcription dosage is controlled by switching the proportion of active and inactive rDNA gene variants |
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20.10 - 20.20 |
Holger Bierhoff: Metabolic control of rRNA synthesis: TIF-IA teams up with epigenetics |
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20.20 - 20.40 |
Luis Aragón: Cdc14 inhibits transcription by RNA Polymerase I during anaphase |
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20.40 - 21.00 |
Ann Beyer: Ribosomal RNA transcription in the context of extreme negative torsional stress in budding yeast cells lacking topoisomerase |
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21.00 - 21.20 |
Attila Németh: High-resolution, genome-wide mapping and characterisation of nucleolus-associated DNA |
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9.00 - 12.30 |
session 2: chair: Pierre Thuriaux |
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9.00 - 9.10 |
introduction: rDNA transcription. The machine and its controls. |
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9.10 - 9.30 |
Sebastian Geiger: Functional architecture of RNA polymerase I |
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9.30 - 9.50 |
Olivier Gadal: Conservation of specific subunits of RNA polymerase I from budding yeast to human |
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9.50 - 10.10 |
David Schneider: The Paf1 complex plays an important, direct |
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10.10 - 10.30 |
Joost Zomerdijk: Topoisomerase II controls the kinetics of |
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10.30 - 10.50 |
break |
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10.50 - 11.00 |
Aziz El Hage: Site-specific RNA polymerase I pausing and pre-rRNA cleavage in the 5’ region of the 18S rDNA in Saccharomyces cervisiae |
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11.00 - 11.20 |
Jean-Jacques Diaz: Uncoupling ribosome biogenesis from RNA polymerase I activity. |
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11.20 - 11.40 |
Savraj Grewal: TOR-dependent regulation of ribosome synthesis during the Drosophila development |
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11.40 - 12.00 |
Oded Meyuhas: The role of the TSC-mTOR pathway in |
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12.00 - 12.20 |
Tom Moss: Growth regulation, epigenetic silencing and tumour suppression in ribosome biogenesis |
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12.30 - 13.50 |
lunch |
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13:50 – 17.30 |
session 3: chair: David Tollervey |
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13.50 - 14.00 |
introduction |
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14.00 - 14.15 |
Susan Gerbi: Evolution of ribosomal RNA: eukaryotic conserved sequences and ribosome biogenesis |
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14.15 - 14.30 |
Martin Koš: Quantitative analyses and modelling of the ribosomal RNA processing in yeast |
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14.50 - 15.05 |
José-Luis Prieto: Transcription of ribosomal genes and processing of pre-ribosomal RNA are coupled |
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15.05 - 15.25 |
Katrin Karbstein: A conformational change regulates cleavage to generate the 3’ End of 18S rRNA |
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15.25 - 15.45 |
break |
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15.45 - 16.05 |
Min Yao: The structure of the archaeal ribosomal stalk complex: insights into the function of translation factor recruitment in eukarya/archaea mode |
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16.05 - 16.25 |
Ger Pruijn: The role of RNase MRP and the exosome in the maturation of 5.8S rRNA in human cells |
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16.25 - 16.45 |
Aarti Sahasranaman: A functional cluster of assembly factors regulate the exonuclease Rat1 to create precise 5’ ends of 5.8S rRNA and is necessary for construction of the polypeptide exit tunnel |
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16.45 - 17.05 |
Sander Granneman: Towards a comprehensive map of protein-RNA interactions in yeast pre-ribosomes; UV cross-linking and analysis of cDNAs (CRAC) reveals novel insights into protein functions and pre-rRNA processing mechanisms. |
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19.00 - 20.00 |
Conference Dinner / opening words by the Mayor of Regensburg |
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20.00 – 22.00 |
session 4: special lectures: |
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9.00 - 11.00 |
session 5: session 5: quality control and degradation |
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9.00 - 9.20 |
Jonathan Warner: Introduction and pseudo-haploinsufficiency for a ribosomal protein has many outcomes |
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9.20 - 9.40 |
Christopher Merrikh: Characterization of nonfunctional rRNA decay in yeast |
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9.40 - 9.50 |
Makato Kitabatake: A role for ubiquitin in the clearance of nonfunctional rRNAs |
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9.50 - 10.00 |
Philip Farabaugh: Effects of haploinsufficiency of ribosomal protein and assembly factor genes on cellular physiology mediated by RACK1 |
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10.00 - 10.10 |
Dimitri Pestov: Role of ubiquitination in regulation of ribosome stability |
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10.10 - 10.30 |
Georgeta Basturea: Mechanism of ribosome degradation during starvation in Escherichia coli. |
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10.30 - 10.50 |
break |
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10.50 - 12.30 |
session 6: snoRNPs |
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10.50. - 11.00 |
introduction |
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11.00 - 11.20 |
Jonathan Dinman: Global rRNA pseudouridylation defects result in impairments in ribosome ligand binding and increased programmed -1 ribosomal frameshifting in yeast and human cells. |
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11.20 - 11.40 |
Christiane Branlant: Archaeal sRNPs and eukaryal snoRNPs: structure, assembly and mechanism of action |
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11.40 - 12.00 |
Nick Watkins: Identification of novel snoRNP-ribosomal RNA interactions through a comprehensive analysis of yeast Box C/D snoRNP structure and function |
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12.00 - 12.10 |
Stuart Maxwell: Archaeal and eukaryotic box C/D RNPs possess evolutionarily conserved structural and functional features essential for RNA-guided nucleotide methylation |
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12.10 - 12.20 |
Franziska Bleichert: Functional importance of the di-sRNP structure of archaeal methylation-guide box C/D sRNPs |
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12.20 - 12.30 |
Celine Verheggen: Trafficking of Box C/D snoRNP to nucleoli involves the hypermethylase Tgs1 in a CRM1-dependent manner |
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13.00 - 15.30 |
lunch and poster viewing (odd page numbers) |
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session 7: enzymatic activities |
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15.30 - 15.40 |
Yves Henry: introduction |
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15.40 - 16.00 |
Balaji Prakash: Structure function relationships in a circularly permuted GTPase, YqeH, involved in ribosome biogenesis. |
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16.00 - 16.20 |
Xinhua Ji: Structure of ERA in complex with the 3′ end of 16S rRNA: Implications for ribosome biogenesis |
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16.20 - 16.40 |
Isabelle Iost: SrmB, an RNA helicase involved in Escherichia coli ribosome assembly, is specifically targeted to 23S rRNA in vivo |
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16.40 - 17.00 |
break |
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17.00 - 17.10 |
Nicolas Leulliot: Structure of the yeast Prp43p helicase involved in splicing and ribosome biogenesis. |
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17.10 - 17.30 |
Markus Bohnsack: The RNA helicase Prp43 has two major binding sites on the yeast pre-rRNA - with distinct functions in pre-rRNA cleavage and snoRNA release |
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17.30 - 17.50 |
Brigitte Pertschy: RNA helicase Prp43 and its co-factor Pfa1 promote 20S to 18S rRNA processing catalyzed by the D-site specific endonuclease Nob1 |
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17.50 - 18.00 |
Lisa Kappel: The AAA-protein Drg1 interacts with the nuclear pore complex and is essential for early steps in cytoplasmic pre-60S ribosome maturation |
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18.30 |
dinner in the „Spital Biergarten“ |
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9.00 - 11.00 |
session 8: assembly of prokaryotic ribosomes |
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9.00 - 9.10 |
introduction |
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9.10 - 9.30 |
James Williamson: Bacterial ribosome assembly in vitro and in cells |
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9.30 - 9.50 |
Gloria Culver: Studies of small ribosomal subunit biogenesis in bacteria |
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9.50 - 10.10 |
Janine Maddock: Assembly of the E. coli 50S particle |
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10.10 - 10.20 |
Stefan Nord: RimP: a new player in 30S assembly |
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10.20 - 10.30 |
Janice Zengel: Analysis of macrolide-resistant Deinococcus radiodurans strains shows that r-protein L4 is dispensable for assembly and function of the 50S ribosomal subunit |
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10.30 - 10.40 |
Claudio Gualerzi: Ribosomal RNA synthesis and ribosomal subunits assembly during cold-acclimation of cold-shocked Escherichia coli cells |
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10.40 - 11.00 |
break |
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11.00 - 12.30 |
session 9: |
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11.00 - 11.10 |
introduction |
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11.10 - 11.30 |
Carl Correll: Contributions of RNA chaperone activity to ribosome biogenesis |
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11.30 - 11.50 |
Anthony Henras: The evolutionary conserved function of Tlr1 in early cleavages of the pre-ribosomal RNA and the production of the 40S ribosomal subunit |
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11.50 - 12.00 |
Nicole LaRonde-LeBlanc: Structural and functional characterization of the role of Nep1 in ribosomal RNA processing |
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12.30 - 15.00 |
lunch and poster viewing (even page numbers) |
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15.00 - 17.30 |
continuation of session 9: assembly and maturation |
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15.00 - 15.20 |
Arlen Johnson: Yvh1 is required for exchange of P0 for Mrt4 to facilitate assembly of the ribosomal stalk |
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15.20 - 15.40 |
Vikram Panse: Yvh1 is required for a late maturation step on the 60S biogenesis pathway |
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15.40 - 16.00 |
María Rodríguez-Mateos: Deletion of the MRT4 gene causes premature assembly of ribosomal protein P0, which results in the formation of functional ribosomes carrying significant structural differences. |
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16.00 - 16.10 |
break |
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16.10 - 16.30 |
Pierre-Emmanuel Gleizes: Overview of the role of the ribosomal proteins in maturation and nuclear export of the 40S ribosomal subunit in mammals |
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16.30 - 16.50 |
Thomas Wild: Ribosome biogenesis in human cells analyzed by systematic RNAi |
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16.50 - 17.10 |
Ed Hurt: The Rea1 AAA ATPase forms a unique mechnochemical pulling device to remove non-ribosomal factors from nuclear 60S pre-ribosome |
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17.10 - 17.30 |
break |
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17.30 - 18.30 |
session 10: |
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17.30 - 17.40 |
introduction |
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17.40 - 18.00 |
Ananth Bommakanti: Mechanisms of correlation of ribosome assembly and cell cycle control |
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18.00 - 18.20 |
Fabrizio Loreni: PIM1 oncoprotein is destabilized by ribosomal stress and inhibits cell cycle progression |
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18.20 - 18.30 |
Jane Lin: Novel mechanisms by which ribosomal proteins regulate growth and proliferation |
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19.30 |
Banquet Haus Heuport |
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9.00 - 9.50 |
continuation of session 10: |
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9.00 - 9.20 |
Stefano Fumagalli: Translational upregulation of rpL11 mediates p53 induction in response to inhibition of 40S ribosome biogenesis. |
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9.20 - 9.40 |
Keiko Mizuta: Ribosome assembly factors, Ebp2 and Rrs1, involved in telomere maintenance with a nuclear envelope SUN protein in budding yeast |
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9.40 - 9.50 |
Mercedes Dosil: A specific mutation reveals a role for the pre-ribosomal factor Rrp12 in the DNA-damage response |
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9.50 – 10.10 |
break |
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10.10 - 13.10 |
session 11: links between ribosomes, disease and aging |
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10.10 – 10.20 |
introduction |
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10.20 - 10.40 |
Hanna Gazda: Identification of new mutations in ribosomal protein genes in Diamond-Blackfan Anemia |
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10.40 - 10.50 |
Tamayo Uechi: Loss of ribosomal protein s19 leads to defective erythropoiesis in a zebrafish model of Diamond-Blackfan anemia |
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10.50 - 11.00 |
Anna Aspesi: Transcriptional and proteomic analyses in RPS19 deficient TF1 cells |
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11.00 - 11.20 |
Dirk Eick: Nucleolar targets of chemotherapy involved in cell cycle and growth control |
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11.20 - 11.40 |
Alan Warren: Structural and genetic approaches to elucidate Sdo1 function in Tif6 recycling |
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11.40 - 12.00 |
break |
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12.00 - 12.20 |
Steven Ellis: Inhibition of Histone Deacetylase Activity Suppresses the 60S Subunit Maturation Defect in a Yeast Model of Shwachman Diamond Syndrome |
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12.20 - 12.40 |
Tom Meier: X- Linked Dyskeratosis Congenita is a ribonucleoprotein assembly deficiency |
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12.40 - 12.50 |
Hannelore Breitenbach-Koller: Translation associated pathomechanisms in autism linked to ribosomal protein rpL10? |
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12.50 - 13.10 |
Matt Kaeberlein: A conserved role for ribosomal proteins in aging and age-associated disease |
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13.00 |
lunch / end of conference |
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