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Programme
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Monday 15th | Tuesday 16th | Wednesday 17th | Thursday 18th
14:00-18:00 Arrival and registration
18:00-19:30 Opening reception and dinner
Session 1: Opening session
Chair: Jerry Shay
19:30 – 19:55 Susan Smith (The Skirball Institute, USA)
Sister telomere cohesion is essential for telomere integrity and genome stability
19:55 – 20:10 Jerome Dejardin (Harvard Medical School, USA)
PICh reveals the protein composition of human telomeres in immortal cell lines
20:10 – 20:35 Yuji Chikashige (Kansai Research Inst, Japan)
Inner nuclear membrane proteins required for the chromosomal bouquet arrangement in Schizosaccharomyces pombe
20:35 – 20:50 Helder Ferreira (FMI, Switzerland)
A role for telomerase and Mps3 in telomere anchoring in budding yeast
20:50 – 21:15 Steve Artandi (Stanford Univ, USA)
A new human telomerase holoenzyme component required for telomere synthesis in vivo.
Session 2: Telomere replication and length regulation
Chair: Duncan Baird
9.00 – 9.25 Lea Harrington (Wellcome Trust Center Edinburgh, UK)
The Effects Of Telomerase Loss In An In Vitro Generated Tumor Cell Model
9.25 – 9.50 Vincent Geli (Univ. of Marseille, France)
Recruitment of telomeric proteins to the leading and lagging telomeres
9.50 – 10.05 Timothy Humphrey (Univ. of Oxford, France)
Suppressing chromosome healing in fission yeast
10.05 – 10.20 Hani Ebrahimi (University of Aberdeen, UK)
Release of yeast telomeres from the nuclear periphery is triggered by replication and maintained by suppression of Ku80 anchoring
Coffee Break
10.50 – 11.15 Joachim Lingner (ISREC, Switzerland)
TERRA: lessons from budding yeast and human cells
11.15 – 11.30 Antonin Morillon (CGM-CNRS, France)
Cryptic subtelomeric Y’ ncRNAs and telomere stability in budding yeast
11.30 – 11.45 Dudy Tzfati (The Hebrew University of Jerusalem, Israel)
A functional three-way junction element is conserved in telomerase RNAs from budding yeasts and vertebrates
11.45 – 12.00 Kathy Friedman (Vanderbilt University, USA)
Regions of S. Cerevisae Est1p that medicate its multiple roles in telomerase assembly.
12.00– 12.25 Jerry Shay (UT Southwestern, USA)
Genome-wide Human shRNA Screening to Dissect Pathways Involved in Telomerase Action
12.45 Lunch
Session 3: Chromatin structure and telomere structure
Chair: Claus Azzalin
16.00 – 16.25 Raymund Wellinger (Univ of Sherbrooke, Canada)
A histone modification cascade involved in the passage through S-phase of cells with damaged DNA.
16.25 – 16.40 Alison Bertuch (Baylor College of Medicine, USA)
Ku must load onto the telomeric end in order to mediate its telomeric functions
16.40 – 16.55 Ed Louis (University of Nottingham, UK)
Genome Instability Associated with ALT in Yeast
16.55 – 17.10 Paula Martinez (CNIO Madrid, Spain)
Telomere rejuvenation by reprogramming
Coffee Break
17.40 – 18.05 Jan Karlseder (Salk Inst, USA)
C. elegans as a model for telomere length regulation in cancer
18.05 – 18.20 Yikang Rong (National Cancer Institute, USA)
Loss of the histone variant H2A.Z restores capping to “checkpoint defective” telomeres in Drosophila
18.20 – 18.35 Toru Nakamura (University of Illinois at Chicago, USA)
Cell Cycle-regulated Dynamics of Fission Yeast Telomere Proteins
18.35 – 19.00 Daniela Rhodes (Cambridge, UK)
Telomerase recruitment by the ciliate telomere end-binding protein TEBPb facilitates G quadruplex DNA unfolding
19.15 Dinner
20.30 Poster Session I
Session 4: Consequences of telomere dysfunction
Chair: Susan Bailey
09.00 – 09.25 Dorothy Shippen (Texas A&M Univ, USA)
Arabidopsis encodes two TERs with distinct functions in telomere maintenance.
09.25 – 09.50 Eric Gilson (Ecole Normal Superior, France)
TRF2 couples the 5’-exonuclease activity of Apollo to telomere replication
09.50 – 10.15 Roger Reddel (Children’s Med, Sydney, Australia)
Induction of Alternative lengthening of Telomeres (alt) – Associated pml bodies by P53/P21 – mediated senescence.
10.15 – 10.30 Chantal Autexier (McGill University, Canada)
Sensitization of Cancer cells to Chemotherapeutic drugs by expression of a mutant telomerase RNA.
Coffee Break
11:00 – 11.25 Stephane Marcand (CEA Fontenay, France)
Use of a conditional centromere to stabilize and select individual telomere-telomere fusions in yeast cells defective for NHEJ-inhibition at telomeres
11.25 – 11.40 Sandy Chang (MD Anderson Cancer Center, USA)
Role of MRE11 in Dysfunctional Telomere – initiated DNA damage response and repair.
11.40 – 11.55 Miguel Godinho Ferreira (Instituto Gulbenkian de Ciancia, Portugal)
Telomeres prevent checkpoints in spite of ongoing DNA repair
11.55 - 12.20 Peter Lansdorp (Terry Fox Laboratories, Canada)
Inborn hypomorhic TERT mutations predispose for hematological malignancies
12.30 Lunch
Session 5: Processing of DNA double strand breaks and/or telomeres
Chair: Carolyn Price
19.30 – 19.55 Rodney Rothstein (Columbia Univ, USA)
Differential processing of endonuclease-mediated and IR- induced DSBs
19.55 – 20:20 Kurt Runge (Cleveland Clinic, USA)
Differential Recruitment of the ATM-family Kinases Tel1p and Mec1p to Telomeres
20:20 – 20.35 Maria Eugenia Gallego (Univ Blaise Pascal, France)
Absence of Xpf/Ercc1 dramatically potentiates chromosome instability in Arabidopsis tert mutants.
20.35 – 20.50 Michael Lisby (University of Copenhagen, Denmark)
Sumoylation and chromosome end structure determines the DNA damage response to short telomeres
Coffee Break
21.15 – 21.30 Alain Nicolas (Institut Curie, France)
Destabilization of the G-quadruplex forming human minisatellite CEB1 in the absence of Pif1 in S. cerevisiae
21.30 – 21.45 Karel Riha (Austrian Academy of Sciences, Austria)
Processing of Arabidopsis telomeres by exonuclease 1
21.45 – 22.10 Martin Kupiec (Tel Aviv Univ, Israel)
Telomere Length control in Yeast: Vertical and Horizontal Views
Session 6: Telomere proteins and protein modifications
Chair: Jurg Heierhorst
09.00 – 09.25 Ming Lei (Univ of Michigan, USA)
Structural mechanism of TRF1 ubiquitination by SCFFBX4
09.25 – 09.40 Grazia Raffa (University of Rome La Sapienza, Italy)
Terminin, a Drosophila protein complex with analogies to human shelterin
09.40 – 09:55 Zhou Songyang (Baylor College of Medicine, USA)
Mechanisms of telomere maintenance by mammalian telomeric proteins
09:55 – 10:20 David Lydall (Univ of Newcastle, UK)
Modulating the response to uncapped telomeres
Coffee Break
10.50 – 11:15 Fuyuki Ishikawa (Kyoto Univ, Japan)
Shelterin complex in fission yeast
11:15 – 11.40 Peter Baumann (Stowers Inst., USA)
Telomerase Biogenesis and Regulation
11.40 – 11.55 Vitaliy Kuznetsov (Cancer Research UK)
Pot1 phosphorylation regulates DNA damage checkpoint inactivation at telomeres
11.55 – 12:20 Carolyn Price (Univ of Cincinnatti, USA)
Novel Tetrahymena proteins that protect telomeres and participate in telomere replication or new telomere synthesis.
12.30 Lunch
14.00 Poster Session II
Session 7: DNA damage response and telomeres
Chair: Lea Harrington
16.00 – 16.25 Jiri Lukas (Univ of Copenhagen, Denmark)
Spatio-temporal organization of signaling and repair factors on damaged chromosomes
16.25 – 16.50 Evi Soutoglou (NIH, USA)
Activation of the Cellular DNA damage response in the absence of DNA lesions
16.50 – 17.05 Manuel Stucki (University of Zurich, Switzerland)
Mechanism of DNA damage-induced MDC1 dimerization
17.05 – 17.20 Stephen Meyn (Hospital for Sick Children, Canada)
The Fanconi anemia pathway plays a critical role in regulating telomeric recombination in ALT-immortalized human cells
17.20 – 17.35Irena Draskovic (Institut Curie, France)
ALT-associated PML bodies are telomere bouquets for recombination
Coffee Break
18.05 – 18.30 Ted Weinert (Univ of Arizona, USA)
How Faulty Template-Switching Generates Gross Chromosomal Rearrangements
18.30 – 18.45Tammy Morrish (John Hopkins University, USA)
Short Telomeres Initiate Telomere Recombination in Primary and Tumor Cells
18.45 – 19.10 Art Lustig (Tulane Univ, USA)
Telomeres and the DNA Damage Response
19.10 – 19.35 Titia de Lange (Rockefeller Univ, USA)
53BP1 promotes NHEJ of telomeres by increasing chromatin mobility
20.00 Closing banquet