Programme
15:00 |
Arrival and Check-in |
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18:00 |
Welcome Cocktail |
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18:30 |
Juan Valcárcel
ICREA and Centre de Regulació Genòmica, Barcelona, Spain Genetic programmes of Alternative Splicing regulation |
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19:00 |
Adrian Krainer
Cold Spring Harbor Laboratory, NY, USA Oncogenic properties of the splicing factor SF2ASF |
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19:30 |
Mariano García Blanco
Duke University Medical Centre, Durham, NC, USA Identification of the cellular targets of the transcription factor CA150 (TCERG1) reveals a widespread role in mRNA processing |
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20:00 |
Dinner
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09:oo |
Nicholas J. Proudfoot
Sir William Dunn School of Pathology, University of Oxford, UK Interconnections between transcripton, RNA processing and gene structure in eukaryotes |
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09:30 |
Alberto R.
Kornblihtt
Laboratorio de Fisiología y Biología Molecular, FCEyN, Universidad de Buenos Aires, Argentina Pol II elongation and factor recruitment in the coupling between transcription and alterntive splicing |
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10:00 |
Christopher W. J. Smith
University of Cambridge, UK Cross-regulation and functional redundancy between PTB and nPTB |
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10:30 |
Javier F. Caceres
MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK Regulation of alternative splicing: Identification of RNA targets for SF2/ASF and hnRNP A1 |
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11:00 |
Coffee break
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11:30 |
Reinhard Lührmann
Max-Planck Institute,
Göttingen, Germany
Assembly and structural dynamics of the spliceosome |
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12:00 |
Angela Kraemer
University of Geneva,
Switzerland
Analysis of SF1 function in alternative splicing |
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12:30 |
Lunch /free time
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16:30 |
Alex Watkins AFFYMETRIX, UK Ltd., High Wycombe, UK
Analysis of Alternative Splicing Using Affymetrix High Density Microarrays
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17:00 |
Jorgen Kjems
University of Aarhus, Denmark A proximal 5’ splice site in HIV-1 stimulates transcriptional initiation |
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17:30 |
James Stévenin
INSERM, IGBMC, Illkirch, France The human RBMY, a potential germline-specific splicing regulator with unique RNA recognition |
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18:00 |
Carlos Suñé
Instituto de Parasitología y Biomedicina Lopez Neyra, Granada, Spain Connection between transcriptional elongation and splicing |
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18:15 |
Jean Beggs
University of Edinburgh, UK Retinitis pigmentosa type 13 mutations affect the interaction of Prp8p with Brr2p and cause a defect in the maturation of U5 snRNPs in yeast |
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18:30 |
Break |
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19:00 |
Giuseppe Biamonti
Istituto di Genetica Molecolare – CNR, Pavia, Italy Alternative splicing of the Ron proto-oncogene: a model system to study the link between regulation of alternative splicing and tumor progression
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19:30 |
Francisco Baralle
International Centre for Genetic Engineering and Biotechnology, Trieste, Italy Influence of the genomic context on splicing efficiency | |
20:00 |
Rossella Tupler
Universita’ di Modena e Reggio Emilia, Italy Analysis of the role of FRG1 in FSHD pathogenesis | |
20:15 |
Dinner |
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21:30 |
Poster Session |
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9:00 |
Benoit Chabot Université de Sherbrooke, Québec, Canada Modern human introns: links with alternative splicing and diseases |
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09:30 |
Igor Vorechovsky University of Southampton, UK Disease gene variants that influence splicing efficiency of weak introns in the 5 leader sequences: lesson from IDDM2 |
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09:45 |
Maria Carmo-Fonseca Instituto de Medicina Molecular, Lisboa, Portugal Splicing defects in oculopharyngeal muscular dystrophy |
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10:15 |
Jane Wu Northwestern University, Chicago, IL, USA Pre-mRNA splicing and Neurodegeneration |
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10:45 |
Jernej Ule MRC Laboratory of Molecular Biology, Cambridge, UK Insights from the RNA map of NOVA-dependent splicing regulations |
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11.00 |
Break |
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11:30 |
Douglas L. Black
HHMI/UCLA, Los Angeles, CA, USA Alternative Splicing and the Regulation of Neuronal Gene Expression |
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12:00 |
Franco Pagani International Centre for Genetic Engineering and Biotechnology, Trieste, Italy Friedrech’s ataxia GAA non-coding repeats expansions affect pre-mRNA processing |
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12:30 |
Lunch / Free Time
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17:00 |
Conxi Lázaro Centre de Genètica Mèdica i Molecular, IRO-IDIBELL, Barcelona, Spain Double genetic characterization (DNA mutation versus RNA effect) of mutations in the NF1 gene: what we have learned about disease-causing splicing mutations |
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17:30 |
Margarida D. Amaral University of Lisboa, Portugal Processing of mRNA in Cystic Fibrosis: Lessons from Native Tissues |
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18:00 |
Marquis Julien University of Bern, Switzerland Complete splicing correction of SMN2 pre-mRNA by a bifunctional modified U7 snRNP |
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18:15 |
Geoff Woods Addenbrookes Hospital, Cambridge, UK Splice variants in important human neuro-developmental genes |
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18:45 |
Break |
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19:00 |
Diana Baralle Addenbrookes Hospital, Cambridge, UK Can we make sense of genotype phenotype correlation? |
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19:30 |
Lia Crotti University of Pavia, IRCCS Policlinico S. Matteo, Pavia, Italy Genotype-phenotype correlation and pre-mRNA splicing defects in the Long QT syndrome |
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20:00 |
Eric White University of Michigan Medical Center, Ann Arbor, MI, USA The role of the EIIIA splice isoform of fibronectin in lung fibrosis |
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20:30 |
Dinner |
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21:30 |
Posert session |
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9:15 |
Christiane Branlant Institute of Bioengineering, UMR 7567 CNRS UHP-Nancy I, Nancy, France Implication of alternative splicing in viral diseases, regulation of HIV-1 RNA splicing |
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09:30 |
Massimo Caputi Florida Atlantic University, Boca Raton, FL, USA Control of HIV-1 mRNA processing |
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10:00 |
Jamal Tazi
Université Montpellier II, France SR proteins in physiological and pathological splicing and as a target for therapy |
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10:30 |
Irene Bozzoni University of Rome “La Sapienza”, Italy Exon skipping for the cure of the Duchenne Muscular Dystrophy |
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11:00 |
Break |
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11:30 |
Stefan Stamm University of Erlangen, Germany Regulation of SMN2 splice site selection by Protein Phosphatase 1 |
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12:00 |
Albrecht Bindereif Justus-Liebig-Universität Giessen, Germany Genome wide regulation of mammalian splicing by CA-rich elements: a combined RNAi and microarray approach |
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12:30 |
End
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Afternoon Session: |
a EURASNET networking and integration round table open to all interested scientists. |
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